医用镁合金体内降解行为与表面改性研究进展  

Progress on the Research of In-vivo Degradation Behavior and Surface Modification of Biomedical Mg Alloys

作　　者：郑洋 张璇 卢佳 何东磊 宿振宇 牛伟[2] 于镇洋[2] 孙荣禄[2] 李岩[3,4] ZHENG Yang;ZHANG Xuan;LU Jia;HE Donglei;SU Zhenyu;NIU Wei;YU Zhenyang;SUN Ronglu;LI Yan(School of Aeronautics and Astronautics,Tiangong University,Tianjin 300387,China;School of Mechanical Engineering,Tiangong University,Tianjin 300387,China;School of Materials Science and Engineering,Beihang University,Beijing 100191,China;Beihang Hangzhou Innovation Institute Yuhang,Hangzhou 310023,China)

机构地区：[1]天津工业大学航空航天学院,天津300387 [2]天津工业大学机械工程学院,天津300387 [3]北京航空航天大学材料科学与工程学院,北京100191 [4]北京航空航天大学杭州创新研究院(余杭),杭州310023

出　　处：《材料导报》2023年第19期137-152,共16页Materials Reports

基　　金：天津市自然科学基金(19JCQNJC02800);国家自然科学基金(51971014)。

摘　　要：医用镁合金具有良好的生物相容性、优异的综合力学性能以及独特的可降解性,是人体非重要承力部位的理想植入材料,但是过快的降解限制了其临床应用。探索更加适合镁合金的植入部位并通过表面改性技术使其降解速率与组织修复过程达到同步是突破临床应用瓶颈的关键。近年来,国内外研究人员研究了体内不同植入环境中镁合金的腐蚀降解机理,利用适当的表面改性技术从涂层成分设计与组织优化角度对医用镁合金的降解行为进行了调控。本文分析了腐蚀介质种类、成分、浓度、流动状态等生理环境对医用镁合金降解行为的影响机制,总结了医用镁合金在骨科、心血管科、消化内科、泌尿外科等植入环境中降解行为的差异,综述了金属涂层、无机非金属涂层、有机高分子涂层、生物功能涂层、复合涂层调控医用镁合金降解行为的研究进展,展望了基于人体特定植入部位开发生物功能性涂层的研究思路,为促进镁合金植入器械的临床应用提供参考。Biomedical Mg alloys are ideal temporary implants in non-important bearing sites in human body due to their good biocompatibility,excellent comprehensive mechanical properties and unique biodegradability.However,fast degradation of Mg alloys in the physiological environment severely restricts their clinical applications.The key solution to solve the problem is exploring more suitable implantation sites for Mg alloys and synchronizing their degradation rate with tissue healing process via appropriate surface modification methods.In recent years,researchers at home and abroad systematically studied their degradation mechanism in different in-vivo environments.They also conducted various surface mo-dification methods to regulate their corrosion behavior by preparing coatings with suitable composition and microstructure.First of all,this paper analyzes the effects of physiological environment(including kinds,compositions,concentrations,flow conditions of the corrosive media)on the degradation behavior of Mg alloys.Then,this paper summarizes the degradation behavior of Mg alloys in different implantation sites of orthopedics,cardiovascular,gastroenterology,urology departments.Following that,this paper reviews the research progress in degradation behavior regulation of Mg alloys using various kinds of coatings such as metallic coatings,inorganic non-metallic coatings,organic polymer coatings,biological functional coatings and composite coatings.Finally,this paper puts forward some development directions of bio-functional coatings based on different specific implantation sites,which could provide reference for promoting the clinical applications of Mg alloys.

关 键 词：生物医用金属 可降解镁合金 降解行为 表面改性 耐蚀涂层 

分 类 号：TG178[金属学及工艺—金属表面处理]