Synthetic biology to revive microbial natural product discovery  

作　　者：Xiaoyu Tang 

机构地区：[1]Shenzhen Bay Laboratory,Institute of Chemical Biology,Shenzhen,China

出　　处：《mLife》2023年第2期123-125,共3页微生物（英文）

基　　金：support from the National Natural Science Foundation of China(82173719);Guangdong Province's Pearl River Recruitment Program of Talents(2021QN02Y855);Shenzhen Bay Laboratory Start‐up Funds(21230051);the Shenzhen Bay Laboratory Open Program(SZBL2021080601007);the Shenzhen Bay Scholar Fellowship.

摘　　要：Microbial natural products(MNPs)and their derivatives have historically played critical roles in drug discovery.However,the discovery of novel MNPs over the last 60 years,through traditional strategies,has declined significantly.Advances in genome sequencing technologies have rapidly changed the direction of natural product research in recent years,providing opportunities to revive the natural product discovery pipeline.Here,I highlight several paradigms combining genomics with synthetic biology to enable MNP discovery and envision future opportunities.

关 键 词：PRODUCT enable CRITICAL 

分 类 号：Q93[生物学—微生物学]