一测多评法在含生物碱类成分中药质量控制中的应用研究  

Applicability of QAMS in Quality Control of Chinese Medicinal Materials Containing Alkaloids

作　　者：张璐[1] 龚旭昊[1] 范强[1] 顾进华[1] ZHANG Lu;GONG Xu-hao;FAN Qiang;GU Jin-hua(China Institute of Veterinary Drugs Control,Beijing 10081,China)

机构地区：[1]中国兽医药品监察所,北京100081

出　　处：《中国兽药杂志》2023年第9期50-63,共14页Chinese Journal of Veterinary Drug

基　　金：“十四五”国家重点研发计划项目“兽用中药质量控制、有效性和安全性评价技术研究”课题(2022YFD1801105)。

摘　　要：生物碱(alkaloid)是广泛分布于中药中的一类含氮有机化合物,其显著的药理活性和疗效已被大量研究文献和临床应用证实。在全球抗微生物药物耐药性背景下,生物碱类中药凭借其良好的抗菌、抗病毒活性广受关注。一测多评(quantitative analysis of multi-components by single maker,QAMS)法是一种适用于中药多成分质量控制的检测方法,可在缺少对照品条件下实现对多个待测成分的同步分析检测,在中药质量控制和评价领域得到较好验证和发展。本文梳理近15年QAMS法在生物碱类中药质量控制中的应用情况,系统分析常见问题并提出解决方法,以期为QAMS法的正确应用提供一些参考。Alkaloids are a kind of nitrogen-containing organic compounds and widely distributed in Chinese medicinal materials(CMMs).The significant pharmacological activity and therapeutic effects of alkaloids have been confirmed by a large number of research literature and clinical application.Due to global antimicrobial resistance,alkaloids have attracted much attention because of their antibacterial and antiviral activities.Quantitative analysis of multi-components by single maker(QAMS)can be used to determine multiple components of CMMs at the some time in the case of a shortage of reference materials.It has been well developed and validated in the QC and evaluation of CMMs for more than ten years since it was put forward.Based on the investigation of QAMS theory and literatures in the past decade,studies on the QC of CMMs and related preparations containing alkaloids by QAMS were summarized and discussed systematically.In addition,some possible problems were analyzed and interpreted,in order to provide reliable basis for more QC of CMMs and reference for the continuous use and in-depth development of this method in the research of CMMs.

关 键 词：中药 一测多评法 生物碱 质量控制 

分 类 号：S859.79[农业科学—临床兽医学]