二黄牡丹汤治疗慢性盆腔炎后遗症疗效观察及对血清IL-8、MCP-1、MMP-2水平的影响  

Curative Observation of Erhuang Mudan Decoction for Sequelae of Pelvic Inflammatory Disease and Its Effect of Levels of IL-8,MCP-1 and MMP-2 in Serum

作　　者：孙苗苗 李鹏[1] SUN Miaomiao;LI Peng(Wenzhou Traditional Chinese Medicine Hospital of Zhejiang Chinese Medicine University,Wenzhou Zhejiang 325000,China)

机构地区：[1]浙江中医药大学附属温州市中医院,浙江温州325000

出　　处：《新中医》2023年第14期93-97,共5页New Chinese Medicine

摘　　要：目的:观察二黄牡丹汤治疗慢性盆腔炎后遗症(SPID)的临床疗效及对血清白细胞介素-8 (IL-8)、单核细胞趋化蛋白-1 (MCP-1)、基质金属蛋白酶-2 (MMP-2)水平的影响。方法:将80例SPID患者按随机数表法分为观察组与对照组各40例。对照组采用妇科千金片治疗,观察组采用二黄牡丹汤治疗。比较2组临床疗效、生活质量评分、炎症因子(IL-8、MCP-1、MMP-2)水平、血液流变学指标及不良反应发生率。结果:观察组总有效率为92.50%,对照组为75.00%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组血清IL-8、MCP-1、MMP-2水平均较治疗前降低(P<0.05),且观察组IL-8、MCP-1、MMP-2水平均低于对照组(P<0.05)。治疗后,2组全血黏度(高切、中切、低切)、血浆黏度、血沉水平均较治疗前降低(P<0.05),且观察组上述各项指标均低于对照组(P<0.05)。治疗后,2组世界卫生组织生存质量简表中生理、心理、社会关系、环境评分均较治疗前升高(P<0.05),且观察组上述各项评分均高于对照组(P<0.05)。对照组出现胃脘不适2例(5.00%),观察组无出现明显不良反应;2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:二黄牡丹汤治疗SPID能够提高临床疗效,降低血清炎症因子水平,改善血液高凝高黏状态,改善患者生活质量,且安全性较好。Objective:To observe the clinical effect of Erhuang Mudan Decoction for sequelae of pelvic inflammatory disease(SPID)and its effect on levels of interleukin-8(IL-8),monocyte chemotactic protein 1(MCP-1),and matrix metalloproteinase-2(MMP-2)in serum.Methods:A total of 80 cases of SPID patients were divided into the observation group and the control group according to the random number table method,with 40 cases in each group.The control group was treated with Gynecologic Qianjin Tablets,and the observation group was treated with Erhuang Mudan Decoction.The clinical effects,scores of quality of life,levels of inflammatory factors including IL-8,MCP-1,and MMP-2,hemorheology indexes,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate was 92.50%in the observation group and 75.00% in the control group,the difference being significant(P<0.05).After treatment,the levels of IL-8,MCP-1,and MMP-2 in serum in the two groups were decreased when compared with those before treatment(P<0.05),and the levels of IL-8,MCP-1,and MMP-2 in the observation group were lower than those in the control group(P<0.05).After treatment,the levels of whole blood high viscosity,whole blood middle viscosity,whole blood low viscosity,plasma viscosity,and erythrocyte sedimentation rates in the two groups were decreased when compared with those before treatment(P<0.05),and the above indexes in the observation group were lower than those in the control group(P<0.05).After treatment,the scores of physiology,psychology,social relations,and environment in WHOQOL-BREF in the two groups were increased when compared with those before treatment(P<0.05),and the above scores in the observation group were higher than those in the control group(P<0.05).There were two cases(5.00%)of gastric discomfort in the control group,and no significant adverse reaction in the observation group;there was no significant difference being found in the comparison of incidence of adverse reactions between the two groups(P>0.

关 键 词：慢性盆腔炎后遗症 二黄牡丹汤 白细胞介素-8 单核细胞趋化蛋白-1 基质金属蛋白酶-2 

分 类 号：R711.33[医药卫生—妇产科学]