肩袖损伤修复的生物治疗进展及展望  

Progress and prospect of biological treatment for rotator cuff injury repair

作　　者：尹正勃 陈志安 尹妮 朱弈霏 张必欢 周田华 谭洪波 徐永清 YIN Zhengbo;CHEN Zhian;YIN Ni;ZHU Yifei;ZHANG Bihuan;ZHOU Tianhua;TAN Hongbo;XU Yongqing(Graduate School of Kunming Medical University,Kunming Yunnan,650500,P.R.China;Department of Renal Rheumatology Immunology,the Third Xiangya Hospital of Central South University,Changsha Hunan,410013,P.R.China;Graduate School of Dali University,Dali Yunnan,671003,P.R.China;Department of Orthopedics,920th Hospital of Joint Logistics Support Force of Chinese PLA,Kunming Yunnan,650032,P.R.China)

机构地区：[1]昆明医科大学研究生院,昆明650500 [2]中南大学湘雅三医院肾脏风湿免疫科,长沙410013 [3]大理大学研究生院,云南大理671003 [4]中国人民解放军联勤保障部队第九二〇医院骨科,昆明650032

出　　处：《中国修复重建外科杂志》2023年第9期1169-1176,共8页Chinese Journal of Reparative and Reconstructive Surgery

基　　金：云南省骨科与运动康复临床医学研究中心资助项目(ZX20191001)。

摘　　要：目的对近年来肩袖损伤修复的生物治疗研究进展进行综述,以期为肩袖损伤修复临床决策提供依据。方法广泛查阅近年来国内外肩袖损伤生物治疗相关文献,对富血小板血浆、生长因子、干细胞及外泌体等生物治疗方式的机制和疗效进行总结。结果为减轻患者疼痛,改善上肢功能,提高生活质量,肩袖损伤治疗经历了从保守治疗向开放式手术到关节镜下肩袖修复术的重要转变,关节镜下肩袖修复联合各种生物治疗方式逐渐成为临床治疗的主流方向。各种生物治疗方式对促进肩袖损伤修复的中、远期临床疗效均较理想,但促进肩袖损伤愈合的生物治疗方式仍存在争议,尚待进一步研究。结论各种生物治疗方式对肩袖损伤修复均展现出较好疗效,进一步研发新型生物治疗技术并验证其有效性将是重要研究方向。Objective To review the research progress in biotherapy of rotator cuff injury in recent years,inorder to provide help for clinical decision-making of rotator cuff injury treatment.Methods The literature related tobiotherapy of rotator cuff injury at home and abroad in recent years was widely reviewed,and the mechanism and efficacyof biotherapy for rotator cuff injury were summarized from the aspects of platelet-rich plasma(PRP),growth factors,stemcells,and exosomes.Results In order to relieve patients’pain,improve upper limb function,and improve quality of life,the treatment of rotator cuff injury experienced an important change from conservative treatment to open surgery toarthroscopic rotator cuff repair.Arthroscopic rotator cuff repair plus a variety of biotherapy methods have become themainstream of clinical treatment.All kinds of biotherapy methods have ideal mid-and long-term effectiveness in therepair of rotator cuff injury.The biotherapy method to promote the healing of rotator cuff injury is controversial andneeds to be further studied.Conclusion All kinds of biotherapy methods show a good effect on the repair of rotator cuffinjury.It will be an important research direction to further develop new biotherapy technology and verify its effectiveness.

关 键 词：肩袖损伤 生物治疗 富血小板血浆 干细胞 生长因子 外泌体 

分 类 号：R686[医药卫生—骨科学]