肌肉衰减综合征患者认知功能障碍患病率的Meta分析  

The prevalence of cognitive impairment in patients with sarcopenia:a meta-analysis

作　　者：黄佳慧 罗强强 李敏[1] 李菁[1] HUANG Jiahui;LUO Qiangqiang;LI Min;LI Jing(School of Nursing,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100144,P.R.China)

机构地区：[1]中国医学科学院北京协和医学院护理学院,北京100144

出　　处：《中国循证医学杂志》2023年第9期1039-1045,共7页Chinese Journal of Evidence-based Medicine

基　　金：老年糖尿病合并肌肉衰减症患者跌倒风险及相关因素研究基金(编号:PUMCSON202309)。

摘　　要：目的系统评价肌肉衰减综合征患者认知功能障碍的患病率。方法计算机检索PubMed、EMbase、Web of Science、Cochrane Library、CBM、CNKI、VIP和WanFang Data数据库,搜集与研究目的相关的研究,检索时限均为建库至2022年12月10日。由2名研究者独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用Stata 14.0软件进行Meta分析。结果共纳入27个研究。Meta分析结果显示,肌肉衰减综合征患者认知功能障碍的总患病率为36.1%[95CI%(29.4%,42.8%)]。亚组分析结果显示,欧洲地区肌肉衰减综合征患者认知功能障碍的患病率高于其他地区;养老院居民患病率最高。结论当前证据显示,肌肉衰减综合征患者认知功能障碍的总患病率较高。受纳入研究数量和质量的限制,上述结论尚待更多高质量研究予以验证。Objective To systematically review the prevalence of cognitive impairment in patients with sarcopenia.Methods The PubMed,EMbase,Web of Science,Cochrane Library,CBM,CNKI,VIP and WanFang Data databases were electronically searched to collect studies related to the objectives from inception to December 10,2022.Two reviewers independently screened literature,extracted data and assessed the risk of bias of the included studies.Meta-analysis was then performed by using Stata 14.0 software.Results A total of 27 studies were included.The overall prevalence rate of cognitive impairment in sarcopenia was 36.1%(95%CI 29.4%to 42.8%).Subgroup analysis showed that the prevalence in Europe was higher than that in other areas.The prevalence of nursing home residents was highest.Conclusion Current evidence shows that the prevalence of cognitive impairment in patients with sarcopenia is high.Due to the limited quality and quantity of the included studies,more high quality studies are needed to verify the above conclusion.

关 键 词：肌肉衰减综合征 认知功能障碍 痴呆 患病率 系统评价 META分析 

分 类 号：R685[医药卫生—骨科学] R749.1[医药卫生—外科学]