含有序微纳米结构的生物材料用于创面修复的研究进展  

Research progress of biomaterials with ordered micro-nano structure in wound repair

作　　者：陶怡冰 施可庆[1] 肖健[1] Tao Yibing;Shi Keqing;Xiao Jian(Laboratory of Translational Medicine,Wound Repair and Regeneration Center,the First Affiliated Hospital of Wenzhou Medical University,Wenzhou 325000,China;Department of Pharmacy of Taizhou Hospital of Zhejiang Province,Taizhou 318050,China)

机构地区：[1]温州医科大学附属第一医院创面修复与再生中心,转化医学实验室,温州325000 [2]浙江省台州医院药剂科,台州318050

出　　处：《中华烧伤与创面修复杂志》2023年第9期896-900,共5页Chinese Journal of Burns And Wounds

基　　金：中国高校产学研创新基金(2021JH041);温州医科大学基本科研业务费立项项目重点项目(KYYW202108)。

摘　　要：许多致伤因素,包括烧伤、手术等均可能导致皮肤结构和功能的破坏,合适的创面敷料或植入物是促进创面愈合与再生的物质基础。含微纳米结构的生物材料能够影响细胞行为,促进细胞顺应结构进行有序生长,将该类材料应用于创面修复中可促进血管新生、调节免疫反应、减少瘢痕面积。近年来,含有序微纳米结构的生物材料在组织工程中的应用得到了广泛关注。该文介绍了几种含有序微纳米结构的生物材料的结构和制备方法,并重点讨论了生物材料表面微结构如何影响创面愈合及其分子机制,以期为临床上创面的治疗寻找和研制更贴近皮肤组织结构的医学生物材料。Many injury-causing factors,including burns and surgery,etc.,can lead to the destruction of structure and function of skin.Suitable wound dressing or implant is the material basis to promote wound healing and regeneration.Biomaterials with micro-nano structure can affect cell behavior,promote orderly growth of cell in accordance with the structure.Their application in wound healing can promote angiogenesis,regulate immune response,and reduce scar area.In recent years,the application of biomaterials with ordered micro-nano structure in tissue engineering has attracted extensive attention.This paper introduces the structure and preparation methods of several biomaterials with ordered micro-nano structure,and focuses on how the surface microstructure of biomaterials affects the process of wound healing and its molecular mechanism,in order to find and develop medical biomaterials that are closer to the skin tissue structure for clinical wound treatment.

关 键 词：伤口愈合 组织工程 纳米纤维 生物相容性材料 沟槽 微纳米结构 

分 类 号：R318.08[医药卫生—生物医学工程] R641[医药卫生—基础医学]