经典名方人参败毒散的历史沿革与现代临床应用  

History and Modern Clinical Application of Classical Formulas Renshen Baidusan

作　　者：张薇 熊珮宇 刘俊宇 胡恒昶 宋丽 刘兴隆[1] 贾波[1] ZHANG Wei;XIONG Peiyu;LIU Junyu;HU Hengchang;SONG Li;LIU Xinglong;JIA Bo(School of Basic Medical Sciences,Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China)

机构地区：[1]成都中医药大学基础医学院,成都610075

出　　处：《中国实验方剂学杂志》2023年第19期60-71,共12页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金面上项目(82074327)。

摘　　要：目的:梳理人参败毒散的历史沿革及现代临床应用。方法:采用文献计量学与统计学相结合的方法,选择古籍数据库及中国知网(CNKI)数据库,检索人参败毒散的相关文献,根据纳入排除标准,提取朝代、书名、功能、剂量等信息,考证与分析方剂历史沿革、组成与剂量、主治病证、煎服方法、药物基原、炮制及现代临床应用等。结果:人参败毒散首载于《太平惠民和剂局方》(简称《局方》),方由柴胡、甘草、桔梗、人参、川芎、茯苓、枳壳、前胡、羌活、独活、生姜、薄荷组成,有散寒祛湿、益气解表功效。后世治疗病证多在《局方》上继承发展,其中感冒(112次)最多,占总病证的22.63%;其次为时行感冒(83次),占16.77%。人参败毒散现代临床应用广泛,涉及各科,呼吸系统疾病(42次)最多,占17.65%;其次为皮肤疾病(34次),占14.29%;再者为传染性疾病(33次),占13.87%。临证加减运用,究其病机或正虚外感,或外感风寒湿邪而正气不虚,充分体现中医异病同治的理念。结论:对经典名方人参败毒散进行考证,确定人参败毒散关键信息,为中医临床研究及复方制剂开发和应用提供依据。Objective:To summarize the history and modern clinical application of Renshen Baidusan.Method:The bibliometric method was used to retrieve the relevant publications of Renshen Baidusan from the ancient book database and China National Knowledge Infrastructure(CNKI).The publications were screened according to the inclusion and exclusion criteria.The information of dynasty,book title,function,dosage and so on was extracted,on the basis of which the history,composition,dosage,decocting method,original medicinal plants,processing,and modern clinical application of this prescription were analyzed.Result:Renshen Baidusan was first recorded in the Formulary of the Bureau of Taiping People's Welfare Pharmacy,consisting of Bupleuri Radix,Glycyrrhizae Radix et Rhizoma,Platycodonis Radix,Ginseng Radix et Rhizoma,Chuanxiong Rhizoma,Poria,Aurantii Fructus,Peucedani Radix,Notopterygii Rhizoma et Radix,Angelicae Pubescentis Radix,Zingiberis Rhizoma Recens,and Menthae Haplocalycis Herba and with the effect of dispersing cold,removing dampness,reinforcing Qi,and relieving exterior.Later generations of physicians used this prescription on the basis of the record in Formulary of the Bureau of Taiping People's Welfare Pharmacy to treat cold(frequency of 112,22.63%) and seasonal cold(frequency of 83,16.77%).Renshen Baidusan is widely used in modern clinical practice to treat respiratory diseases(frequency of 42,17.65%),skin diseases(frequency of 34,14.29%),and infectious diseases(frequency of 33,13.87%).This prescription is often modified to treat the syndrome of internal deficiency and external contraction,or external contraction of wind,cold and damp pathogens without deficiency of healthy Qi,which fully embodies the concept of treating different diseases with the same method in traditional Chinese medicine.Conclusion:The textual research reveals the key information of the classical prescription Renshen Baidusan,providing a basis for the subsequent development and application of compound preparations.

关 键 词：经典名方 人参败毒散 文献考证 临床应用 

分 类 号：R2-0[医药卫生—中医学] R33R289