重症COVID-19合并轻度脑炎或脑病伴可逆性胼胝体压部病变1例  

Severe COVID-19 complicated with mild encephalitis/encephalopathy with reversible splenial lesion of the corpus callosum:a case report

作　　者：王康 赵慧 郑修竹 巩凤超 何喜英 赵同 Wang Kang;Zhao Hui;Zheng Xiuzhu;Gong Fengchao;He Xiying;Zhao Tong(Department of Neurology,the Second Affiliated Hospital of Shandong First Medical University,Taian 271000,China;Department of Imaging,the Second Affiliated Hospital of Shandong First Medical University,Taian 271000,China)

机构地区：[1]山东第一医科大学第二附属医院神经内科,泰安271000 [2]山东第一医科大学第二附属医院影像科,泰安271000

出　　处：《中华神经科杂志》2023年第9期1055-1059,共5页Chinese Journal of Neurology

摘　　要：自新型冠状病毒全球大流行以来,导致COVID-19的SARS-CoV-2感染与一系列疾病有关,针对这些疾病非典型表现的报道日渐居多,其中轻度脑炎或脑病伴可逆性胼胝体压部病变(MERS)是一种罕见的临床和影像学综合征。目前对COVID-19引起MERS的发病机制尚不明确,其发病机制可能包括缺氧性损害、炎性反应、免疫紊乱、渗透压的改变、兴奋性氨基酸毒性作用、氧化应激反应及肾素-血管紧张素系统功能异常等。文中报道1例重症COVID-19合并MERS患者的临床资料,并从病理生理学角度对发其病机制进行探讨。Since the global COVID-19 pandemic,SARS-CoV-2 infection,which causes COVID-19,has been associated with a range of diseases whose atypical manifestations have been increasingly reported.The mild encephalitis or encephalopathy associated with reversible corpus callosum lesions or mild encephalitis/encephalopathy with reversible splenial lesion(MERS)is a rare clinical and radiographic syndrome.At present,the pathogenesis of MERS caused by COVID-19 is still unclear,and its pathogenesis may include hypoxic damage,inflammatory response,immune disorders,changes in osmotic pressure,excitatory amino acid toxicity,oxidative stress and functional abnormalities of renin-angiotensin system.This paper reports a case of severe COVID-19 complicated with MERS,and discusses the pathogenesis from a pathophysiological point of view.

关 键 词：新型冠状病毒 胼胝体 细胞毒性 免疫 发病机制 

分 类 号：R511[医药卫生—内科学] R742[医药卫生—临床医学]