Evolution of focused streams for viscoelastic flow in spiral microchannels  

作　　者：Hua Gao Jian Zhou Mohammad Moein Naderi Zhangli Peng Ian Papautsky 

机构地区：[1]Department of Biomedical Engineering,University of Illinois Chicago,Chicago,IL 60607,USA

出　　处：《Microsystems & Nanoengineering》2023年第3期129-143,共15页微系统与纳米工程（英文）

基　　金：We gratefully acknowledge partial funding support of the Richard and Loan Hill Department of Biomedical Engineering at the University of Illinois Chicago and the Center for Advanced Design and Manufacturing of Integrated Microfluidics(NSF I/UCRC award IIP-1841473).

摘　　要：Particle migration dynamics in viscoelastic fluids in spiral channels have attracted interest in recent years due to potential applications in the 3D focusing and label-free sorting of particles and cells.Despite a number of recent studies,the underlying mechanism of Dean-coupled elasto-inertial migration in spiral microchannels is not fully understood.In this work,for the first time,we experimentally demonstrate the evolution of particle focusing behavior along a channel downstream length at a high blockage ratio.We found that flow rate,device curvature,and medium viscosity play important roles in particle lateral migration.Our results illustrate the full focusing pattern along the downstream channel length,with side-view imaging yielding observations on the vertical migration of focused streams.Ultimately,we anticipate that these results will offer a useful guide for elasto-inertial microfluidics device design to improve the efficiency of 3D focusing in cell sorting and cytometry applications.

关 键 词：VISCOELASTIC flow CURVATURE 

分 类 号：O35[理学—流体力学]