Tau蛋白的传播扩散与相关免疫反应的研究进展  

Seeding and immune response of Tau protein in Alzheimer’s disease

作　　者：王宗宝 李森[1,2] WANG Zongbao;LI Sen(College of Life Sciences,Beijing Normal University,100875,Beijing,China;National Demonstration Center for Experimental Life Sciences&Biotechnology Education,Beijing Normal University,100875,Beijing,China)

机构地区：[1]北京师范大学生命科学学院,北京100875 [2]北京师范大学生命科学与技术国家级实验教学示范中心,北京100875

出　　处：《北京师范大学学报（自然科学版）》2023年第4期542-547,共6页Journal of Beijing Normal University(Natural Science)

基　　金：国家自然科学基金资助项目(31570756,32071222),北京市教育委员会共建基金资助项目。

摘　　要：Tau蛋白的异常聚集作为阿尔茨海默病(Alzheimer’s disease,AD)发病机制的重要组成部分,一直以来是国内外的研究热点.自Tau蛋白聚集体具有种子效应这一现象被发现以来,Tau病理种子的形成、传播与抑制过程作为治疗AD疾病新的治疗方向被广泛研究,但具体的相关机制尚不明确.本文对目前Tau蛋白的复杂性、Tau病理种子的形成与传播、种子传播的免疫抑制方面的相关研究进行总结,阐述了Tau病理种子传播的可能机制,可为未来AD疾病的治疗提供新的方向.The abnormal aggregation of Tau protein is an important cause for the pathogenesis of Alzheimer’s disease(AD).Since the seed effect of Tau protein aggregates was discovered,the formation,propagation and inhibition of Tau seeds have been widely studied,but specific mechanisms remain unclear.The complexity of Tau protein,the formation and spread of Tau seeds,and immunosuppression effect of Tau seed spreading were summarized.The possible mechanism of Tau seeds spreading was described,with certain clinical implications for the treatment of AD.

关 键 词：Tau病理种子 跨细胞传播 突触连接传播 释放与摄取 免疫反应 

分 类 号：Q71[生物学—分子生物学] Q518.1