流行性出血热患者血清CK-MB、IL-6、IL-10水平与病情程度、预后的关系研究  

Study on the Relationship between Serum CK-MB,IL-6,IL-10 Levels and Disease Severity and Prognosis in Patients with Epidemic Hemorrhagic Fever

作　　者：饶建锋[1] 李珊 RAO Jianfeng;LI Shan(The Ninth Hospital of Nanchang,Nanchang 330002,China;不详)

机构地区：[1]南昌市第九医院,江西南昌330002

出　　处：《中国医学创新》2023年第27期137-141,共5页Medical Innovation of China

摘　　要：目的:分析流行性出血热(EHF)患者血清肌酸激酶同工酶(CK-MB)、白细胞介素-6(IL-6)及白细胞介素-10(IL-10)水平与病情程度、预后的关系。方法:回顾性选择2019年6月—2022年6月于南昌市第九医院进行治疗的EHF患者60例作为本次研究对象,按照病情严重程度分为以下三组:轻症组(n=28,轻型、中型患者)、重症组(n=19,重型患者)及危重症组(n=13,危重型患者)。检测其入院后第1、3、7天的CK-MB、IL-6及IL-10水平,分析以上3项实验室检查指标与患者病情严重程度的相关性,并依据90 d预后情况分为存活组与死亡组,分析CK-MB、IL-6、IL-10与EHF患者预后的关系。结果:轻症组入院第1、3、7天血清CK-MB、IL-6、IL-10水平均低于重症组及危重症组(P<0.05),重症组以上指标水平均低于危重症组(P<0.05)。血清CK-MB、IL-6、IL-10水平与病情严重程度成正相关(rs=0.562、0.355、0.301,P<0.05)。60例患者随访90 d发现存活54例,死亡6例,存活组入院后第1、3、7天血清CK-MB、IL-6及IL-10水平均明显低于死亡组(P<0.05);受试者操作特征(ROC)曲线分析显示,入院第1天血清CK-MB、IL-6、IL-10单独及联合检测均对EHF患者预后有预测价值(P<0.05),其中联合检测的预测效能最高,其AUC为0.849,敏感度为98.14%,特异度为59.16%。结论:EHF患者血清CK-MB、IL-6及IL-10水平与病情发展呈正相关,可用于评估病情严重程度及预后,且三者联合时的效能最高。Objective:To analyze the relationship between serum creatine kinase MB(CK-MB),interleukin-6(IL-6)and interleukin-10(IL-10)levels and disease severity and prognosis in patients with epidemic hemorrhagic fever(EHF).Method:A total of 60 patients with EHF who were treated in the Ninth Hospital of Nanchang from June 2019 to June 2022 were retrospectively selected as the subjects of this study,and divided into the following three groups according to the severity of the disease:mild group(n=28,light and medium patients),severe group(n=19,severe patients)and critical group(n=13,critical patients).The levels of CK-MB,IL-6 and IL-10 at the 1st,3rd and 7th day after admission were detected,and the correlation between the above three laboratory examination indexes and the severity of the patients'disease were analyzed.The patients were divided into survival group and death group according to the prognosis of 90 days,and the relationship between CK-MB,IL-6 and IL-10 and the prognosis of EHF patients were analyzed.Result:The serum levels of CK-MB,IL-6 and IL-10 in mild group were lower than those in severe group and critical group at 1,3 and 7 days after admission(P<0.05),and the above indexes in severe group were lower than those in critical group(P<0.05).Serum CK-MB,IL-6 and IL-10 levels were positively correlated with the severity of the disease(rs=0.562,0.355,0.301,P<0.05).After 90 days of follow-up,54 patients survived and 6 died.The levels of serum CK-MB,IL-6 and IL-10 in the survival group were significantly lower than those in the death group at 1,3 and 7 days after admission(P<0.05).Receiver operating characteristic(ROC)curve analysis showed that serum CK-MB,IL-6 and IL-10 alone and combined detection on the first day of admission had predictive value on the prognosis of EHF patients(P<0.05),and the combined detection had the highest predictive efficacy,with AUC of 0.849,sensitivity of 98.14%and specificity of 59.16%.Conclusion:Serum CK-MB,IL-6 and IL-10 levels in patients with EHF are positively correlated with the d

关 键 词：流行性出血热 肌酸激酶同工酶 白细胞介素-6 白细胞介素-10 预后 

分 类 号：R512.8[医药卫生—内科学]