丹参多酚酸盐辅助用于急性心肌梗死经皮冠状动脉介入术围术期临床观察  

Clinical Observation of Salvia Miltiorrhiza Polyphenolate in the Adjuvant Treatment of Patients with Acute Myocardial Infarction Undergoing Elective Percutaneous Coronary Intervention During Perioperative Period

作　　者：胡小春 叶丛 马瑞松 周燕[1] 李海涛[1] HU Xiaochun;YE Cong;MA Ruisong;ZHOU Yan;LI Haitao(Hainan Provincial People′s Hospital,Haikou,Hainan,China 570311)

机构地区：[1]海南省人民医院,海南海口570311

出　　处：《中国药业》2023年第18期93-97,共5页China Pharmaceuticals

基　　金：海南省卫生计生行业科研项目[18A200149]。

摘　　要：目的探讨丹参多酚酸盐辅助用于择期行经皮冠状动脉介入术(PCI)急性心肌梗死(AMI)患者的效果。方法选取医院2018年8月至2021年8月收治的择期行PCI的AMI患者102例,按随机数字表法分为观察组和对照组,各51例。两组患者均予AMI二级预防治疗并择期行PCI,术后均予抗血小板聚集治疗等;观察组患者于术前1周至术后1周加用注射用丹参多酚酸盐。结果观察组总有效率为94.12%,显著高于对照组的80.39%(P<0.05)。与对照组比较,观察组患者术后即刻心肌梗死溶栓治疗(TIMI)血流分级为Ⅲ级的患者占比显著高于对照组(P<0.01);与对照组比较,观察组术后7 d左室收缩末期容积、左室舒张末期容积及血清乳酸脱氢酶、肌酸激酶同工酶、肌酸激酶、羟丁酸脱氢酶、脑钠肽、内皮素-1水平及miR-1,miR-208b,miR-146a表达水平均显著降低(P<0.05),左室射血分数、一氧化氮水平均显著升高(P<0.05)。结论丹参多酚酸盐用于择期行PCI的AMI患者,可有效提高其血管疏通后心肌血流灌注,改善心功能,减轻术后心肌损伤,提高血管内皮功能,同时可调节血miR-1,miR-208b,miR-146a的表达水平。Objective To investigate the efficacy of salvia miltiorrhiza polyphenolate in the adjuvant treatment of patients with acute myocardial infarction(AMI)undergoing elective percutaneous coronary intervention(PCI).Methods A total of 102 AMI patients undergoing elective PCI admitted to the hospital from August 2018 to August 2021 were selected and divided into the observation group and the control group by the random number table method,with 51 cases in each group.The patients in the two groups were given secondary preventive treatment for AMI,elective PCI,and were given antiplatelet aggregation treatment after surgery.On this basis,the patients in the observation group were given Salvia Miltiorrhiza Polyphenolate for Injection from one week before surgery to one week after surgery.Results The total effective rate in the observation group was 94.12%,which was significantly higher than 80.39%in the control group(P<0.05).Compared with that in the control group,the proportion of patients with the immediate thrombolysis in myocardial infarction(TIMI)blood flow grading following surgery of gradeⅢin the observation group was significantly higher than that in the control group(P<0.01).Compared with those in the control group,the left ventricular end-systolic volume(LVESV),left ventricular end-diastolic volume(LVEDV),serum lactate dehydrogenase(LDH),creatine kinase-MB(CK-MB),creatine kinase(CK),hydroxybutyrate dehydrogenase(HBDH),brain natriuretic peptide(BNP),endothelin-1(ET-1)levels,miR-1,miR-208b and miR-146a expression levels 7 d after surgery in the observation group significantly decreased(P<0.05),and the left ventricular ejection fraction(LVEF)and nitric oxide(NO)levels 7 d after surgery in the observation group significantly increased(P<0.05).Conclusion The application of salvia miltiorrhiza polyphenolate in AMI patients undergoing elective PCI can effectively improve myocardial perfusion after vascular patency,improve cardiac function,alleviate postoperative myocardial injury,increase vascular endothelial function,

关 键 词：丹参多酚酸盐 经皮冠状动脉介入术 急性心肌梗死 围术期 微小RNA 心功能 辅助治疗 

分 类 号：R969.4[医药卫生—药理学]