中成药和经典名方治疗脑水肿的药理及临床研究进展  

Pharmacological and clinical research progress of Chinese patent medicine and classical prescriptions in treatment of cerebral edema

作　　者：薛子卓 姚宇晴 张燕欣 陈璐 万梅绪[3,4] 李智 吕欣 庄朋伟 李德坤[3,4] 鞠爱春[3,4] XUE Zizhuo;YAO Yuqing;ZHANG Yanxin;CHEN Lu;WAN Meixu;LI Zhi;LÜXin;ZHUANG Pengwei;LI Dekun;JU Aichun(Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Hebei University of Traditional Chinese Medicine,Shijiazhuang 050200,China;Tianjin Tasly Pride Pharmaceutical Co.,Ltd.,Tianjin 300410,China;Tianjin Key Laboratory of Safety Evaluation Enterprise of Traditional Chinese Medicine Injections,Tianjin 300410,China)

机构地区：[1]天津中医药大学,天津301617 [2]河北中医学院,河北石家庄050200 [3]天津天士力之骄药业有限公司,天津300410 [4]天津市中药注射剂安全性评价企业重点实验室,天津300410

出　　处：《药物评价研究》2023年第8期1794-1801,共8页Drug Evaluation Research

摘　　要：脑水肿是缺血性脑卒中、脑出血、脑积水、肝衰竭等多种疾病的继发性症状,临床上治疗脑水肿的中成药主要有丹参类制剂(包括丹参注射液、复方丹参注射液和丹红注射液)和三七类制剂(三七颗粒和血塞通注射液),它们具有活血化瘀、改善血液循环的作用;经典名方桃核承气汤具有逐瘀泻热的功效,通过活血化瘀、利水作用来改善脑水肿。其药理作用主要是通过水通道、离子通道起作用,主要靶点为水通道蛋白、离子通道蛋白、血液中的基质金属蛋白酶。对相关中成药及经典名方治疗脑水肿的药理及临床研究进行归纳总结,以期为治疗该病的新药研发及临床合理用药提供依据。Brain edema is a secondary symptom of ischemic cerebral infarction,cerebral hemorrhage,hydrocephalus,liver failure and other diseases.Clinically,Chinese patent medicines for the treatment of cerebral edema include Danshen preparations(such as Danshen Injection,Compound Danshen Injection and Danhong Injection)and Sanqi preparations(such as Sanqi Granules and Xuesaitong Injection),which have the effect of promoting blood circulation and removing blood stasis to improve blood circulation.The classic prescription for the treatment of cerebral edema is Taohe Chengqi Decoction,which has the effect of expelling stasis and purging heat.It can improve cerebral edema by promoting blood circulation and removing blood stasis and promoting diuresis.The treatment of cerebral edema mainly works through water channels and ion channels,and the main targets are aquaporins,ion channel proteins,and matrix metalloproteinases in the blood.In this study,the related Chinese patent medicines and traditional Chinese medicine decoctions in the treatment of cerebral edema were summarized by consulting the literature,in order to provide a basis for the development and rational use of new drugs for treating cerebral edema.

关 键 词：脑水肿 中成药 经典名方 丹参注射液 丹红注射液 血塞通注射液 桃核承气汤 

分 类 号：R286.1[医药卫生—中药学]