麦冬提取物及其有效成分的药理作用研究进展  

Research progress on pharmacological effects of extracts and active components of Ophiopogon japonicus

作　　者：万梅绪[1,2] 原景 张燕欣 李智 鞠爱春 李德坤 王蕴华[1,2] WAN Meixu;YUAN Jing;ZHANG Yanxin;LI Zhi;JU Aichun;LI Dekun;WANG Yunhua(Tianjin Tasly Pride Pharmaceutical Co.,Ltd.,Tianjin 300410,China;Tianjin Key Laboratory of Safety Evaluation Enterprise of Traditional Chinese Medicine Injections,Tianjin 300410,China)

机构地区：[1]天津天士力之骄药业有限公司,天津300410 [2]天津市中药注射剂安全性评价企业重点实验室,天津300410

出　　处：《药物评价研究》2023年第8期1819-1826,共8页Drug Evaluation Research

摘　　要：麦冬来源于百合科植物麦冬Ophiopogon japonicus的干燥块根,有养阴生津,润肺清心的功效。麦冬的化学成分丰富,主要成分有甾体皂苷类、高异黄酮类、多糖类等,具有保护心血管、保护消化系统、抗肿瘤、保护神经系统、改善肝、肺损伤、抗炎抗氧化、降糖、抗衰老、免疫调节等药理作用。主要对麦冬皂苷B、麦冬皂苷D、麦冬多糖、麦冬水提物及醇提物的药理作用进行全面综述,以期为麦冬的深度开发以及新药研发提供参考。Radix Ophiopogonis is the dried root of Ophiopogon japonicus,its character is slightly cold,has nourishing Yin and promoting production of fluid,moistening the lung and clearing the heart effect.Ophiopogon japonicus is rich in chemical components,the main components are steroid saponins,high isoflavones and polysaccharides,which have pharmacological effects such as protection of cardiovascular system,protection of digestive system,anti-tumor,protection of nervous system,improvement of liver and lung injury,anti-inflammatory,antioxidant,hypoglycemic,anti-aging and immune regulation.The pharmacological effects of ophiopogonin B,ophiopogonin D,ophiopogon polysaccharide and the water extracts and alcohol extracts of Ophiopogon japonicus in recent years were roundly reviewed in order to provide reference for the further development of Ophiopogon japonicus and the research and development of new drugs.

关 键 词：麦冬 麦冬提取物 麦冬皂苷 麦冬多糖 保护心血管 抗肿瘤 抗氧化 

分 类 号：R285.5[医药卫生—中药学]