五味子提取物及其有效成分对心血管疾病的药理作用研究进展  

Research progress on pharmacological effects of Schisandrae Chinensis Fructus extracts and its active components on cardiovascular diseases

作　　者：李智 李汶泽 倪秀一 万梅绪[1,2] 张燕欣 李德坤 王蕴华[1,2] 鞠爱春 LI Zhi;LI Wenze;NI Xiuyi;WAN Meixu;ZHANG Yanxin;LI Dekun;WANG Yunhua;JU Aichun(Tianjin Tasly Pride Pharmaceutical Co.,Ltd.,Tianjin 300410,China;Tianjin Key Laboratory of Safety Evaluation Enterprise of Traditional Chinese Medicine Injections,Tianjin 300410,China;Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Heibei University of Chinese Medicine,Shijiazhuang 050200,China)

机构地区：[1]天津天士力之骄药业有限公司,天津300410 [2]天津市中药注射剂安全性评价企业重点实验室,天津300410 [3]天津中医药大学,天津301617 [4]河北中医学院,河北石家庄050200

出　　处：《药物评价研究》2023年第8期1827-1832,共6页Drug Evaluation Research

摘　　要：五味子是常用中药材之一,在保肝、治疗心脑血管疾病等方面发挥重要作用,其主要活性成分包括木脂素类、多糖类、挥发油及有机酸等成分。对五味子提取物及其有效成分治疗心血管疾病的抗心肌炎症、抗氧化损伤、抑制心肌细胞凋亡、缓解心肌纤维化等药理作用及其机制进行综述,发现五味子总木脂素可以调节核因子-κB信号通路、激活氮合酶途径抑制炎症因子及心肌细胞的凋亡,五味子乙素调节酪氨酸激酶2蛋白/信号转导子与激活子3信号通路抑制氧化损伤,五味子提取物抑制Smad蛋白信号传导发挥舒张心血管作用。Schisandrae Chinensis Fructus is one of the commonly used Chinese medicine in clinic.It plays an important role in protecting liver and treating cardiovascular and cerebrovascular diseases.Its main active ingredients include lignans,polysaccharides,volatile oils and organic acids.The pharmacological effects and mechanisms of Schisandrae Chinensis Fructus extract and its active components in the treatment of cardiovascular diseases,such as anti-myocardial inflammation,anti-oxidative damage,inhibition of cardiomyocyte apoptosis and alleviating myocardial fibrosis,were reviewed.It was found that the total lignan of Schisandrae Chinensis Fructus can regulate the nuclear fact-κB signaling pathway,activate the nitrogen synthase pathway and inhibit inflammatory factors and cardiomyocyte apoptosis.Schisandrin regulates tyrosine kinase 2/signal transductor and activator 3 signaling pathways to inhibit oxidative damage,and Schisandrae Chinensis Fructus extracts inhibit Smad protein signal transduction to exert diastolic cardiovascular effects.

关 键 词：五味子 五味子总木脂素 五味子乙素 抗心肌炎症 抗氧化损伤 抗心肌细胞凋亡 抗心肌纤维化 

分 类 号：R286.2[医药卫生—中药学]