基于明清医案的当归亦当为解表药数据挖掘研究  

Research on Data Mining of Angelica Sinensis as a Relieving Exterior Drug Based on Ming and Qing Medical Cases

作　　者：余苗苗 薛露 黄辉[2] 杨芹 纪美艳 李娟[1] YU Miaomiao;XUE Lu;HUANG Hui;YANG Qin;JI Meiyan;LI Juan(Anhui University of Chinese Medicine,Hefei 230012,China;Xin'an Medicine Key Laboratory of the Ministry of Education,Anhui University of Chinese Medicine,Key Research Base of Humanities and Social Sciences of the Ministry of Education Huizhou Research Center,Anhui University of Chinese Medicine Branch Center,Hefei 230012,China;People's Hospital of Jinzhai County,Anhui Lu'an 237399,China)

机构地区：[1]安徽中医药大学,安徽合肥230012 [2]安徽中医药大学新安医学教育部重点实验室/教育部人文社科重点研究基地徽学研究中心安徽中医药大学分中心,安徽合肥230012 [3]金寨县人民医院,安徽六安237399

出　　处：《陕西中医药大学学报》2023年第5期48-55,共8页Journal of Shaanxi University of Chinese Medicine

基　　金：2020年安徽省高校协同创新项目(GXXT-2020-037)。

摘　　要：目的通过数据挖掘对明清医案中外感疾病用药规律进行探讨分析,证明当归亦当为一味解表药使用。方法搜集查阅明清医案书籍,从中选取治疗外感疾病医案,得到处方466首,使用Microsoft Excel 2016对处方药物进行频数、四气五味归经分析,应用IBM SPSS Modeler 18.0、Gephi、SPSS Statistics 25.0进行关联规则、复杂网络以及聚类分析。结果共纳入466个处方,涉及中药316味,当归使用频次较高,2项关联得出当归与桂枝、白芍、甘草关系最为密切;复杂网络核心处方主要由桂枝汤、九味羌活汤加减组成;聚类分析共得到9组药物聚类组合。结论明清医案中外感疾病多将当归与辛温解表药配伍使用,共奏解表散寒之效,以发挥当归补血调血兼辛温解表的双重功用,为治疗外感疾病提供了临床新思路。Objective To explore and analyze the medication patterns of exogenous diseases in medical records of the Ming and Qing dynasties through data mining,and to prove that Angelica sinensis should also be used as a relieving exterior drug.Methods Collect and consult medical records of the Ming and Qing dynasties,select medical records for treating exogenous diseases,and obtain 466 prescriptions.Use Microsoft Excel 2016 to analyze the frequency,four Qi and five flavors of prescription drugs,and use IBM SPSS Modeler 18.0,Gephi,and SPSS Statistics 25.0 for association rules,complex networks,and cluster analysis.Results A total of 466 prescriptions were included,involving 316 traditional Chinese drugs.Angelica sinensis was used more frequently,and the two associations showed that Angelica sinensis had the closest relationship with Cinnamon twig,White peony,and Licorice;The core prescription of complex networks mainly consists of Guizhi decoction and Jiuwei Qianghuo decoction;A total of 9 drug cluster combinations were obtained through cluster analysis.Conclusion In the medical records of the Ming and Qing dynasties,Angelica sinensis was often used in combination with Xinwen Jiebiao drug to achieve the effect of relieving external heat and dispersing cold,in order to exert the dual functions of Angelica sinensis in nourishing blood and regulating blood,as well as Xinwen Jiebiao,providing a new clinical approach for the treatment of exogenous diseases.

关 键 词：当归 辛温解表 明清医案 外感疾病 数据挖掘 

分 类 号：R28[医药卫生—中药学]