中医药介导OPG/RANK/RANKL信号通路防治类风湿关节炎的研究进展  

Research progress on the prevention and treatment of traditional Chinese medicine on rheumatoid arthritis by OPG/RANK/RANKL signaling pathway

作　　者：禄成龙 宫玉锁[2] 刘建平 刘晓婷 元宝华 康付平 马亚龙 陈绪帆 赖宇翔 光佳如 Cheng-Long LU;Yu-Suo GONG;Jian-Ping LIU;Xiao-Ting LIU;Bao-Hua YUAN;Fu-Ping KANG;Ya-Long MA;Xu-Fan CHEN;Yu-Xiang LAI;Jia-Ru GUANG(Clinical College of Chinese Medicine,Gansu University of Chinese Medicine,Lanzhou 730000,China;Department of Orthopaedic Trauma,Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou 730000,China;Sports Medicine Research and Exercise Rehabilitation Doctor's Office,Sports Science and Technology Center of Ningxia Hui Autonomous Region,Yinchuan 750001,China)

机构地区：[1]甘肃中医药大学中医临床学院,兰州730000 [2]甘肃省中医院创伤骨科,兰州730000 [3]宁夏回族自治区体育科学技术中心运动医学研究与运动康复诊疗室,银川750001

出　　处：《数理医药学杂志》2023年第9期697-707,共11页Journal of Mathematical Medicine

基　　金：甘肃省自然科学基金项目(23JRRA1239、23JRRA1237);甘肃省重点人才项目和陇原青年创新创业人才(团队)项目(甘组通字〔2022〕77号);甘肃省卫生行业科研计划项目(GSWSKY-2019-89);兰州市科技局人才创新创业项目(2017-RC-58)。

摘　　要：类风湿关节炎(rheumatoid arthritis,RA)是一种临床常见的以滑膜炎为主的自身免疫性疾病。炎性细胞因子和破骨细胞刺激滑膜组织增生、炎症反应、骨质破坏及关节功能障碍等,在RA的致病因素中占据关键位置。本文对中药单体及其提取物、中药复方及制剂、中药配伍,以及中医治疗通过调控骨保护蛋白(osteoprotegerin,OPG)/NF-κB受体激活因子(receptor activator of NF-κB,RANK)/NF-κB配体激活因子(receptor activator of NF-κB ligand,RANKL)信号通路干预RA的相关研究进行综述。结果表明,中药中的有效分子机制不同,但是可以起到调控信号通路的作用,刺激成骨细胞活性,抑制炎性细胞因子分泌,减少破骨细胞分化,从而防治RA,为中医药多靶点、多途径治疗RA提供理论依据。Rheumatoid arthritis(RA)is a common autoimmune disease characterized by synovitis in clinical practice.Inflammatory cytokines and osteoclasts stimulate synovial tissue proliferation,inflammatory reactions,bone destruction,and joint dysfunction,play the key role in the pathogenesis of RA.This article reviews the relevant research on the intervention of RA through the regulation of osteoprotegerin(OPG)/receptor activator of NF-κB(RANK)/receptor activator of NF-κB ligand(RANKL)signaling pathway by traditional Chinese medicine monomers and their extracts,traditional Chinese medicine formulas and preparations,traditional Chinese medicine compatibility,and traditional Chinese medicine treatment.The results indicate that the effective molecular mechanisms in traditional Chinese medicine are different,but they can play a role in regulating signaling pathways,stimulate osteoblast activity,inhibit inflammatory cytokine secretion,reduce osteoclast differentiation,prevent and treat RA.This provides a theoretical basis for the multi target and multi pathway treatment of RA in traditional Chinese medicine.

关 键 词：类风湿关节炎 信号通路 中医药 研究进展 

分 类 号：R259[医药卫生—中西医结合]