Hippo信号通路在糖尿病视网膜病变中的研究进展  

Research progress of Hippo signaling pathway in diabetic retinopathy

作　　者：滕凤舞 李亚娣 许鑫悦 薛黎萍 TENG Fengwu;LI Yadi;XU Xinyue;XUE Liping(Children s Eye Department,Affiliated Hospital of Yunnan University,Yunnan Provincial Eye Hospital,the Second People's Hospital of Yunnan Province,Kunming,Yunnan 650021,China)

机构地区：[1]云南大学附属医院,云南省第二人民医院,云南省眼科医院儿童眼科,云南昆明650021

出　　处：《中国临床研究》2023年第9期1407-1411,共5页Chinese Journal of Clinical Research

基　　金：云南省中青年学术和技术带头人后备人才项目(202005AC160021);云南省科技厅科技计划项目—昆明医科大学应用基础联合专项基金项目(202101AY070001-287)。

摘　　要：糖尿病视网膜病变对糖尿病患者的生活质量产生严重影响。临床上主要采用抗血管内皮生长因子、激光或外科治疗手段,其治疗效果有局限性。亟需更新更有效的预防和治疗方法。Hippo信号通路是一条复杂的激酶链,其包括一系列的激酶和转录因子,参与调控细胞增殖、分化和凋亡等过程。现已证明人眼视网膜中存在典型的Hippo信号通路,其主要影响因子YAP/TEA调控视网膜内皮及血管新生过程。本文通过综述Hippo信号通路的组成、调节机制、在糖尿病视网膜病变与其他信号通路和危险因素的相互关系及相关药物治疗,以期为糖尿病视网膜病变的防治提供更广阔的思路。Diabetic retinopathy has a serious impact on the quality of life of diabetes patients.In clinic,anti-vascular endothelial growth factor,laser or surgical treatment are mainly used,which has limited therapeutic effect,so it is urgent to update more effective prevention and treatment methods.The Hippo signaling pathway is a complex kinase chain that includes a series of kinases and transcription factors involved in regulating processes such as cell proliferation,differentiation,and apoptosis.It has been proved that there is a typical Hippo signaling pathway in the human retina,and its main influencing factor YAP/TEA regulates the process of retinal endothelium and angiogenesis.This article reviews the composition and regulatory mechanism of Hippo signaling pathway,the relationship between Hippo signaling pathway and other signaling pathways and risk factors in diabetic retinopathy,and related drug treatment,in order to provide a broader idea for the prevention and treatment of diabetic retinopathy.

关 键 词：糖尿病视网膜病变 Hippo信号通路 Yes相关蛋白 糖代谢 氧化应激 血管新生 二甲双胍 维替泊芬 炎症反应 

分 类 号：R587.2[医药卫生—内分泌]