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作 者:田丹丹 王善萍[2] 杨丽[2] 张婷婷[2] 何丽 刘天阳[2] 谌曦[2] TIAN Dan-dan;WANG Shan-ping;YANG Li;ZHANG Ting-ting;HE Li;LIU Tian-yang;CHEN Xi(First Clinical Medical College,Anhui University of Traditional Chinese Medicine,Hefei Anhui 230031;Department of Rheumatology and Immunology,The First Affiliated Hospital of Anhui University of Chinese Medicine,Hefei Anhui 230031,China)
机构地区:[1]安徽中医药大学第一临床医学院,安徽合肥230031 [2]安徽中医药大学第一附属医院风湿免疫科,安徽合肥230031
出 处:《蚌埠医学院学报》2023年第9期1309-1313,共5页Journal of Bengbu Medical College
基 金:安徽省高校自然科学研究重点项目(KJ2020A0395);安徽中医药大学临床科研基金(2020yfyzc55)。
摘 要:目的:探究系统性红斑狼疮(SLE)病人焦虑抑郁情况及其相关因素。方法:收集202例SLE病人社会人口学资料和评估疾病活动指标,采用焦虑自评量表(SAS)和抑郁自评量表(SDS)评定病人焦虑、抑郁状态,采用单因素、关联规则分析、logistic回归分析焦虑、抑郁和焦虑合并抑郁相关影响因素。结果:202例SLE病人中抑郁发生率43.56%(88/202),焦虑发生率为47.53%(96/202),焦虑合并抑郁发生率为37.13%(75/202)。单因素分析显示,焦虑组医保类型、婚姻状况、年收入情况、就业情况、生育情况、匹兹堡睡眠指数评分(PSQI)是其相关因素(P<0.05~P<0.01);抑郁组医保类型、SLE疾病活动指数(SLEDAI)、PSQI是其相关因素(P<0.01);焦虑合并抑郁组病程、教育程度、医保类型、生育情况、SLEDAI、PSQI是其相关因素(P<0.05~P<0.01)。logistic回归分析结果示SLEDAI、PSQI、医保类型是焦虑合并抑郁的独立危险因素(P<0.05~P<0.01)。其中医保类型是最大危险因素(OR=3.720,P<0.01)。关联规则分析显示,焦虑抑郁状态的发生与SLE病人SLEDAI、PSQI有明显关联。结论:SLE病人容易出现焦虑抑郁状态,与经济状况、疾病活动等因素密切相关。Objective:To study anxiety and depression in patients with systemic lupus erythematosus(SLE)and its related factors.Methods:Social demographic data and disease activity indicators were collected from 202 patients with SLE.Self-rating Anxiety Scale(SAS)and Self-rating Depression Scale(SDS)were used to evaluate anxiety and depression.Univariate,association rule analysis and logistic regression were used to analyze the related influencing factors of anxiety,depression and anxiety combined with depression.Results:Among 202 patients with SLE,the incidence of depression was 43.56%(88/202),the incidence of anxiety was 47.53%(96/202)and the incidence of anxiety combined with depression was 37.13%(75/202).Univariate analysis showed that the medical insurance type,marital status,annual income,employment status,fertility status and Pittsburgh Sleep Quality Index(PSQI)were related factors in the anxious group(P<0.05 to P<0.01),the medical insurance type,systemic lupus erythematosus disease activity index(SLEDAI)and PSQI were related factors in the depression group(P<0.01),while the disease course,education level,medical insurance type,fertility status,SLEDAI,and PSQI were the related factors in the anxiety combined with depression group(P<0.05 to P<0.01).Logistic regression analysis showed that the SLEDAI,PSQI and medical insurance types were independent risk factors for anxiety combined with depression(P<0.05 to P<0.01),among them,the type of medical insurance was the biggest risk factor(OR=3.720,P<0.01).Association rule analysis showed that the incidence of anxiety and depression was significantly associated with SLEDAI and PSQI in SLE patients.Conclusions:SLE patients are prone to anxiety and depression,which is closely related to economic status,disease activity and other factors.
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