糖尿病酮症酸中毒引起极度血小板增多症1例并文献复习  

Extreme thrombocytosis caused by diabetic ketoacidosis:A case report and literature review

作　　者：张欣欣 刘国庆[1] 王蓓蓓[1] Zhang Xinxin;Liu Guoqing;Wang Beibei(Department of Endocrinology,Shengli Oilfield Central Hospital,Dongying 257000,China)

机构地区：[1]胜利油田中心医院内分泌科,山东东营257000

出　　处：《临床荟萃》2023年第8期719-721,共3页Clinical Focus

摘　　要：目的探讨糖尿病酮症酸中毒引起极度血小板增多症的临床特点及治疗。方法回顾性分析胜利油田中心医院收治的1例糖尿病酮症酸中毒引起的极度血小板增多症患者的临床特点及治疗转归。结果本例患者为青年女性,否认血小板增多病史及血液系统其他疾病病史,急性起病,血小板极度增多(多次报危急值),后完善骨髓穿刺活检及相关基因检测排除血液系统疾病,考虑糖尿病性酮症酸中毒导致继发性血小板增多。在充分补液,纠正酮症酸中毒的过程中血小板水平也随之降低,4天内血小板降至正常范围,且在日后随访过程中血小板维持正常水平。结论查阅相关文献,目前国内外尚无糖尿病酮症酸中毒合并血小板极度增多的病例报道,现就此例病例进行报道,以期在临床上发现糖尿病酮症酸中毒合并血小板极度增多时避免误诊及过度治疗。Objective To investigate the clinical characteristics and treatment of extreme thrombocytosis caused by diabetic ketoacidosis.Methods The clinical characteristics and treatment outcomes of a patient with extreme thrombocytosis caused by diabetic ketoacidosis who was treated in Shengli Oilfield Central Hospital were retrospectively analyzed.Results The present young female patient had a sudden onset of an extreme thrombocytosis,with multiple times of reporting critical values.She denied the history of thrombocytosis and other diseases of the blood system.After bone marrow biopsy and gene testing,hematological diseases were excluded,and secondary thrombocytosis caused by diabetic ketoacidosis was considered.Platelet count decreased during the treatment course.After adequate fluid rehydration and correction of ketoacidosis,platelet count returned to the normal range within 4 days,which remained normal during follow-up.Conclusion Through literature review,there is no case report of diabetic ketoacidosis with extreme thrombocytosis at home and abroad.This case report aims to provide reference to avoid misdiagnosis and excessive treatment of diabetic ketoacidosis patients with extreme thrombocytosis.

关 键 词：糖尿病酮症酸中毒 极度血小板增多症 

分 类 号：R587.22[医药卫生—内分泌]