基于苯并噻二唑结构的近红外二区有机小分子在生物成像和治疗中的研究进展  

Advances of NIR-ⅡSmall Organic Molecules in Bioimaging and Therapy Based on Benzothiadiazole Structure

作　　者：景靳彭 陈世棱 王宗樟 陈洪敏 JING Jinpeng;CHEN Shileng;WANG Zongzhang;CHEN Hongmin(State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics&Center for Molecular Imaging and Translational Medicine,Xiamen University,Xiamen 361102,China;State Key Laboratory of Organic Electronics and Information Displays&Institute of Advanced Materials(IAM),Nanjing University of Posts&Telecommunications,Nanjing 210023,China)

机构地区：[1]厦门大学分子疫苗学与分子诊断学国家重点实验室,分子影像暨转化医学研究中心,福建厦门361102 [2]南京邮电大学有机电子与信息显示国家重点实验室,信息材料与纳米技术研究院,江苏南京210023

出　　处：《发光学报》2023年第9期1667-1680,共14页Chinese Journal of Luminescence

基　　金：有机电子与信息显示国家重点实验室开放研究基金资助课题。

摘　　要：基于光子反射、散射和自发荧光的减弱,近红外二区窗口能够实现高分辨率和信噪比的生物荧光成像,在各种生物医学应用中发挥着重要作用。构建供体-受体-供体结构是设计近红外二区有机小分子的有效方法,基于苯并噻二唑结构的近红外二区有机小分子不仅能够实现光学成像,还能利用光激活的激发态能量转换实现光学治疗。本文总结了基于苯并双噻二唑(Benzobisthiadiazole,BBT)和[1,2,5]噻二唑[3,4-g]喹喔啉([1,2,5]thiadiazolo[3,4-g]quinoxaline,TQ)结构的近红外二区有机小分子在生物成像和成像引导的治疗中的研究进展,并对未来近红外二区有机小分子的设计和应用进行了展望。Based on the reduction of photon reflection,scattering and spontaneous fluorescence,NIR-Ⅱwindow enables high resolution and signal-to-noise ratio biofluorescence imaging,which plays an important role in a variety of biomedical applications.The construction of donor-acceptor-donor structure is an effective method for the design of NIR-Ⅱsmall organic molecules.NIR-Ⅱsmall organic molecules based on benzothiadiazole structure can not only realize optical imaging,but also realize phototherapeutics by utilizing the light-activated excited state energy conversion.This review summarizes the research advances of NIR-Ⅱsmall organic molecules based on benzobisthiadiazole(BBT)and[1,2,5]thiadiazolo[3,4-g]quinoxaline(TQ)in bioimaging and image-guided therapy,and prospects of the design and application of NIR-Ⅱsmall organic molecules in the future are presented.

关 键 词：近红外二区 苯并噻二唑 生物成像 光学治疗 

分 类 号：O482.31[理学—固体物理]