Bcl-2蛋白家族调控细胞凋亡机制及其在创面修复中的应用研究进展  

Mechanism of Bcl-2 protein family regulating apoptosis and its application in wound repair

作　　者：唐婷 韦柳叶 黄金梅(综述) 唐乾利(审校)[2] TANG Ting;WEI Liuye;HUANG Jinmei;TANG Qianli(School of Graduate Study,Guangxi University of Traditional Chinese Medicine,Nanning,Guangxi 530000,China;Youjiang Medical College for Nationalities/Key Laboratory of High Incidence Prevention and Control in Western Guangxi,Baise,Guangxi 533000,China)

机构地区：[1]广西中医药大学研究生院,南宁530000 [2]右江民族医学院/桂西高发病防治重点实验室,广西百色533000

出　　处：《重庆医学》2023年第18期2854-2858,共5页Chongqing medicine

基　　金：国家自然科学基金项目(81774327);广西特聘专家专项资助项目(桂人才通字[2019]13号);广西中医药大学研究生教育创新计划项目(桂中医大研[2021]31号)(YCXJ2021069)。

摘　　要：慢性难愈合创面是指不能通过正常、有序的程序及时恢复局部组织解剖和功能完整状态的创面,是临床较为棘手的难题之一。细胞凋亡作为创面愈合过程的关键环节,可及时清除体内多余的细胞及受损细胞,调节机体正常发育和生命活动,在创面愈合过程中发挥了重要作用。近年来研究发现,B细胞淋巴瘤-2(Bcl-2)家族蛋白参与了细胞凋亡的调节,可通过调节其凋亡抑制因子与凋亡诱导因子的比例来抑制细胞凋亡,达到促进创面愈合的目的。基于此,该文对Bcl-2家族蛋白在细胞凋亡中的调控机制及在创面修复中的应用研究进行了综述,旨在为进一步指导Bcl-2家族蛋白在慢性难愈合创面治疗中的应用提供参考。Chronic refractory wounds refer to wounds that cannot restore local tissue anatomy and functional integrity in a timely manner through normal and orderly procedures,which is one of the more difficult clinical problems.As a key link in the process of wound healing,apoptosis can timely remove excess and damaged cells in the body,regulate the normal development and life activities of the body,and play an important role in the process of wound healing.In recent years,some researchers have found that B-cell lymphoma-2 family proteins(Bcl-2 family proteins)are involved in the regulation ofcell apoptosis,by regulating its apoptosis inhibitor and apoptosis-inducing factor ratio to inhibit apoptosis to promote wound healing purposes.Based on this,this paper reviews the regulatory mechanism of Bcl-2 family proteins in apoptosis and their application in wound repair,aiming to provide reference for further guiding the application of Bcl-2 family proteins in the treatment of chronic refractory wounds.

关 键 词：B淋巴细胞瘤-2家族蛋白 细胞凋亡 慢性难愈合创面 创面修复 综述 

分 类 号：R641[医药卫生—外科学]