T细胞在肺上皮细胞损伤与修复中的作用和机制  

Function and mechanisms of T cells in the damage andrepair of lung epithelial cells

作　　者：刘恩卓 刘志纯[1] 温振科 Liu Enzhuo;Liu Zhichun;Wen Zhenke(The Second Affiliated Hospital of Soochow University,Suzhou 215004,Jiangsu China;Institutes of Biology and Medical Sciences,Soochow University,Suzhou 215123,Jiangsu China)

机构地区：[1]苏州大学附属第二医院,江苏苏州215004 [2]苏州大学生物医学研究院,江苏苏州215123

出　　处：《生物医学转化》2023年第3期32-38,46,共8页Biomedical transformation

基　　金：国家自然科学基金项目(82071826,82271841)。

摘　　要：肺上皮细胞在呼吸系统中起着重要的保护作用。然而,各种病理因素如感染、创伤和炎症等可以导致肺上皮细胞的损伤,进而引发呼吸系统疾病。在肺上皮细胞损伤和修复过程中,T细胞扮演着关键角色,并通过接触或者释放多种免疫介质来参与这一过程。不同亚群的T细胞分别承担着增强抗炎反应、清除感染的致炎作用以及促进血管新生和上皮细胞增殖的修复作用。本综述旨在总结T细胞在肺上皮细胞损伤和修复中的作用,并阐述其参与肺疾病发病和缓解的可能机制。Lung epithelial cells play a protective role in the respiratory system.However,various pathological factors such as infection,trauma,and inflammation can lead to damage to lung epithelial cells,causing lung diseases.T cells play a key role in lung epithelial cells damage and repair,and participate in these processes by contacting with respiratory epithelial cells or releasing of various cytokines.Different subpopulations of T cells are responsible for enhancing anti-inflammatory responses,clearing infections,and promoting angiogenesis and epithelial cell proliferation.This review aims to summarize the role of T cells in lung epithelial cell damage and repair,as well as the mechanisms involved in the development and remission of lung diseases.

关 键 词：T细胞 肺上皮细胞 作用及机制 损伤与修复 

分 类 号：R563[医药卫生—呼吸系统] R363.21[医药卫生—内科学]