Semaphorin 3E的研究进展  

Research progress on Semaphorin 3E

作　　者：尹玉纯 陈天平[1] Yin Yuchun;Chen Tianping(The First Affiliated Hospital of Bengbu Medical College,Bengbu,Anhui 233000,China)

机构地区：[1]蚌埠医学院第一附属医院,安徽蚌埠233000

出　　处：《齐齐哈尔医学院学报》2023年第14期1352-1357,共6页Journal of Qiqihar Medical University

基　　金：2022安徽省卫生健康科研项目(AHWJ2022a020)。

摘　　要：信号蛋白(Semaphorins)最初在20世纪90年代初被定性为在神经元系统发育过程中起作用的轴突引导分子。这些分子属于分泌性、膜锚定和跨膜糖蛋白的一个大而多样的家族,族中成员共分为8大类,信号素3E(Semaphorin 3E)是第三类信号蛋白之一,主要受体是丛蛋白(Plxns)和神经蛋白酶(Nrps)。近年来越来越多的研究表明,Sema 3E蛋白在参与免疫系统、血管的生成、肿瘤的发生与转移、心血管系统等多种疾病的生理病理过程中有着重要作用。本综述阐述目前Sema 3E在几种疾病中的研究进展,为以后心血管疾病方面的研究提供方向。Semaphorins were initially identified as axon-guiding molecules that played a role in neuronal phylogenetics in the early 1990s.These molecules belong to a large and diverse family of secreted,membrane-anchored and trans-membrane glycoproteins with members divided into 8 groups.Semaphorin3E is one of the third group of signaling proteins.The main receptors are plexin and neuroprotease.A growing number of studies in recent years have shown that Sema3E protein plays an important role in the physiological and pathological processes of immune system,angiogenesis,tumor occurrence and metastasis,cardiovascular system and other diseases.This review describes the current research progress of Sema3E in the following diseases,and provides directions for future research in cardiovascular diseases.

关 键 词：Semaphorin 3E 心血管疾病 肿瘤 免疫系统 

分 类 号：R392[医药卫生—免疫学]