Kisspeptin在辅助生殖过程中的研究进展  

Advances in the study of kisspeptin in assisted reproduction

作　　者：孙轶群 赵军招[1] SUN Yiqun;ZHAO Junzhao(Department of Reproductive Center,the Second Affiliated Hospital of Wenzhou Medical University,Wenzhou 325000,China)

机构地区：[1]温州医科大学附属第二医院生殖医学中心,浙江温州325000

出　　处：《温州医科大学学报》2023年第9期761-767,共7页Journal of Wenzhou Medical University

摘　　要：Kisspeptin是一种神经肽类物质,通过与KISS1R(G蛋白偶联受体)结合,刺激促性腺激素释放激素释放,进而调控下丘脑-垂体-性腺轴,在女性生殖过程中发挥重要的作用。除下丘脑之外,卵巢、子宫内膜、滋养层等组织与细胞中也发现kisspeptin及其受体KISS1R的表达,局部表达的kisspeptin/KISS1R参与多种生理活动,对卵细胞成熟、胚胎着床等过程意义重大。本文主要就kisspeptin在生殖相关领域,尤其是排卵及着床过程中的进展进行综述,并简述kisspeptin在预测妊娠结局,以及生殖相关疾病如反复移植失败和复发性流产等的潜在意义,以期为kisspeptin在辅助生殖技术中的应用提供思路。Kisspeptin is a neuropeptide that regulates female reproduction by binding to the G proteincoupled receptor KISS1R and stimulating gonadotropin-releasing hormone release,which in turn regulates the hypothalamic-pituitary-gonadal axis.In addition to the hypothalamus,kisspeptin and its receptor KISS1R are also found to be expressed in the ovary,endometrium,trophectoderm and other tissues and cells.The locally expressed kisspeptin/KISS1R involved in a variety of physiological activities is significant for oocyte maturation and embryo implantation.In this paper,we review the progress of kisspeptin in reproduction-related fields,particularly ovulation and implantation,and briefly discuss kisspeptin’s potential significance in predicting pregnancy outcome and reproduction-related diseases such as recurrent transfer failure and recurrent miscarriage,in order to provide ideas for kisspeptin’s application in assisted reproductive technology.

关 键 词：KISSPEPTIN 卵巢 胚胎着床 辅助生殖 

分 类 号：R715.2[医药卫生—妇产科学]