从“阴毒”理论探讨骨转移癌痛病机及治疗  

Exploration of the Pathogenesis and Treatment of Bone Metastatic Cancerous Pain From the Yin Toxicity

作　　者：陈铭昱 祝金标 邬欣悦 王梦雪 孙魏 CHEN Ming-yu;ZHU Jin-biao;WU Xin-yue;WANGMeng-xue;SUN Wei(Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing 210029 Jiangsu,China)

机构地区：[1]南京中医药大学附属医院,江苏南京210029

出　　处：《中医肿瘤学杂志》2023年第5期1-6,共6页Journal of Oncology in Chinese Medicine

基　　金：省部级基金吴阶平医学基金会临床研究课题(编号:320.6750.2021-10-7);国家自然科学基金面上项目(编号:81973609)。

摘　　要：疼痛为肿瘤骨转移患者最常见的症状之一。现代医学治疗骨转移癌痛有其局限性。中医药以其整体观念、辨证论治之核心,在治疗骨转移癌痛上发挥独特优势。“阴毒”一词最先出现于《金匮要略》中,由后世医家不断充实拓展。笔者认为,肿瘤晚期患者符合患者体质为阴、疾病病位为阴、疾病病势为阴之特征,切合“阴毒”病理论内涵,故在此探讨基于“阴毒”的骨转移癌痛病机特点,进一步提出“补肾坚骨,截阻病势”为其治则,“补气生血”“温阳化积”“升阳散毒”三大治法,为临床治疗骨转移癌痛提供参考。Pain is the most common symptom in patients with bone metastases.Modern medical treatment of bone metastatic cancerous pain has its limitations.Traditional Chinese medicine,with the core of holistic concept and syndrome differentiation and treatment,plays a unique advantage in the treatment of bone metastatic cancerous pain.The term“yin toxicity”first appeared in the Synopsis of Golden Chamber,which was continuously enriched and expanded by later generations of practitioners.The author believes that the advanced cancer patients can be classified in the yin category in terms of physical constitution,disease location,and disease condition,which is in line with the connotation of yin toxicity.Consequently,the pathogenesis of bone metastatic cancerous pain is explored based on yin toxicity,therapeutic principles of“tonifying the kidney to strengthen the bone,and cutting off the development of disease”were put forward,and therapies of“replenishing Qi and blood”,“warming yang to resolve retention”,and“elevating yang to eliminate the toxin”were proposed in this paper,thus to provide reference in clinic.

关 键 词：阴毒 骨转移 癌痛 

分 类 号：R273[医药卫生—中西医结合] R738.1[医药卫生—中医肿瘤科]