六神丸联合放疗治疗食管癌的临床研究及对食管癌炎性微环境与抑制血管生成的影响  

Clinical Study of Liushen Pill Combined with Radiotherapy in the Treatment of Esophageal Cancer and Its Effect on Inflammatory Microenvironment and Inhibition of Angiogenesis of Esophageal Cancer

作　　者：赖灿辉[1] 陈佳海[1] 陈云萍[1] 吴清木 LAI Can-hui;CHEN Jia-hai;CHEN Yun-ping;WU Qing-mu(Oncology Department of the 910th Hospital of Chinese PLA Joint Logistics Support Force,Quanzhou 362000 Fujian,China)

机构地区：[1]中国人民解放军联勤保障部队第910医院肿瘤科,福建泉州362000

出　　处：《中医肿瘤学杂志》2023年第5期25-29,共5页Journal of Oncology in Chinese Medicine

基　　金：泉州市卫生领域指导性科技计划(编号:2022N003S)。

摘　　要：目的探究分析六神丸联合放疗治疗食管癌的临床疗效及对食管癌炎性微环境与血管生成的作用机制。方法选取自2020年4月-2022年6月期间就诊并接受治疗的65例食管癌患者为观察对象,将其用随机数字表法分为两组(对照组:32例,观察组:33例)。观察组采取六神丸联合放疗,对照组单纯实施放疗,比较两组患者的临床疗效、治疗前后相关炎性因子水平以及血管内皮生长因子(vascular endothelial growth factor,VEGF)和微血管密度(micro-vascular density,MVD)。结果观察组的治疗总有效率高于对照组(75.76%vs 50%),差异有统计学意义(χ^(2)=4.628,P<0.05);两组患者治疗后,炎性微环境均所有改善,血清C-反应蛋白(C-reactive protein,CRP)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)以及白细胞介素-1β(interleukin-1β,IL-1β)等相关炎性因子指标水平均有所降低,且观察组的改善情况优于对照组,且差异有统计学意义(t=9.276、5.798、4.843,P<0.05);观察组治疗后,其VEGF表达和MVD值都低于对照组,且差异有统计学意义(t=7.169、5.668,P<0.05)。结论六神丸联合放疗治疗食管癌的临床疗效较好,对于食管癌炎性微环境与血管生成的影响较明显,应用价值较高。Objective To investigate the clinical efficacy of Liushen pill combined with radiotherapy in the treatment of esophageal cancer and to explore its therapeutic mechanism on inflammatory microenvironment and angiogenesis of esophageal cancer.Methods A total of 65 patients with esophageal cancer who seek medical consultation in our hospital from April 2020 to June 2022 for treatment were selected as the observation objects.The patients were randomly divided into two groups,32 cases in control group and 33 cases in observation group.The observation group was treated with Liushen pill combined with radiotherapy,while the control group was treated with radiotherapy alone.The clinical efficacy and the pre-and post-treatment levels of related inflammatory factors,vascular endothelial growth factor(VEGF)and microvessel density(MVD)of the two groups were compared.Results(1)The total effective rate of the observation group was higher than that of the control group(75.76%vs 50.00%),with statistically significant difference(χ^(2)=4.628,P<0.05).(2)After treatment,the inflammatory microenvironment of patients in both groups was improved,the levels of inflammatory factors of Creactive protein(CRP)and tumor necrosis factorα(TNF-α)and interleukin 1β(IL-1β)were reduced,and the improvement in the observation group was superior to that in the control group,the differences being statistically significant(t vale being 9.276,5.798,4.843 respectively,P<0.05).(3)After treatment,the VEGF expression and MVD value in the observation group were lower than those in the control group,and the differences were statistically significant(t vale being 7.169,5.668 respectively,P<0.05).Conclusion Liushen Pill combined with radiotherapy has significant clinical effect on esophageal cancer,and is effective on improving the inflammatory microenvironment and angiogenesis of esophageal cancer,with high application value.

关 键 词：食管癌 六神丸 放疗 炎性微环境 血管生成 

分 类 号：R273[医药卫生—中西医结合] R735.1[医药卫生—中医肿瘤科]