表观弥散系数对磁共振引导聚焦超声术治疗子宫肌瘤效果的评估  

Efficacy Evaluation of Apparent Diffusion Coefficient in the Treatment of Uterine Fibroid by Magnetic Resonance Guided Focused Ultrasound Surgery

作　　者：曾雪伟[1] 周守国[1] 黄耀渠[1] 王梓华 何亚男 黄华仪[1] 王娟[1] ZENG Xue-wei;ZHOU Shou-guo;HUANG Yao-qu;WANG Zi-hua;HE Ya-nan;HUANG Hua-yi;WANG Juan(Department of Radiology,Foshan Hospital of Traditional Chinese Medicine,Foshan 528000,China)

机构地区：[1]佛山市中医院医学影像科,广东佛山528000

出　　处：《中山大学学报（医学科学版）》2023年第5期863-869,共7页Journal of Sun Yat-Sen University:Medical Sciences

基　　金：佛山市自筹经费类科技创新项目(2220001005419);佛山市医学重点专科项目(FSZD145011)。

摘　　要：【目的】探讨磁共振表观弥散系数(ADC)评估磁共振引导聚焦超声术(MRgFUS)治疗子宫肌瘤效果的价值。【方法】回顾性分析佛山市中医院2018年1月至2022年10月期间56例接受MRgFUS治疗子宫肌瘤患者治疗前、治疗3月后和6月后的MRI及临床资料,比较患者病灶ADC值与肌瘤的体积,症状严重评分(SSS)和子宫肌瘤症状-生活质量问卷(UFS-QOL)评分的相关性。使用方差分析比较治疗前后相关数据的差异,采用Pearson法进行数据的相关性分析。【结果】56例患者治疗前及治疗3个月后、6个月后病灶ADC值[(1.11±0.13)、(1.84±0.09)、(2.12±0.24),×10^(-3)(/mm^(2)/s)]、肌瘤体积(102±35.30、56.70±18.88、46.93±18.99,cm^(3)),SSS(36.73±11.74、21.77±10.21、17.66±9.30)和UFS-QOL(59.05±17.48、76.54±16.50、82.46±12.37)评分差异有统计学意义(F值分别为557.837,73.589,53.976和37.606,P值均<0.05)。ADC值与肌瘤体积、SSS呈负相关,与UFS-QOL评分呈正相关(相关系数分别为-0.586,-0.630和0.592,P值均<0.05)。【结论】ADC值对评估MRgFUS治疗子宫肌瘤效果具有较好的临床应用价值。【Objective】To assess the value of apparent diffusion coefficient(ADC)in the treatment of uterine fibroid using magnetic resonance guided focused ultrasound surgery(MRgFUS).【Methods】The MRI and clinical data of 56 pa⁃tients with uterine fibroid before,at 3 and 6 months after MRgFUS treatment,at Foshan Hospital of Traditional Chinese Medicine from December 2018 to October 2022,were retrospectively analyzed.The correlation between the ADC value and lesion volume,symptoms severity score(SSS)and uterine fibroid symptoms quality of life questionnaire(UFS-QOL)were analyzed.ANOVA was used to compare the differences in related parameters before and after treatment,and Pearson’s method was performed to analyze data correlation.【Results】There were significant differences in ADC value[(1.11±0.13),(1.84±0.09),(2.12±0.24),×10^(-3)(/mm^(2)/s)],lesion volume(102±35.30,56.70±18.88,46.93±18.99,cm^(3)),SSS(36.73±11.74,21.77±10.21,17.66±9.30)and UFS-QOL score(59.05±17.48,76.54±16.50,82.46±12.37)between be⁃fore treatment and each time point after treatment(F value was 557.837,73.589,53.976 and 37.606,respectively,all P<0.05).The ADC values were negatively correlated with lesion volume and SSS,and positively correlated with UFS-QOL score,with correlation coefficients of-0.586,-0.630 and 0.592,respectively(all P<0.05).【Conclusion】The ADC value has clinical significance for the treatment of uterine fibroid using MRgFUS.

关 键 词：磁共振成像 表观弥散系数 磁共振引导聚焦超声术 子宫肌瘤 消融 

分 类 号：R713.4[医药卫生—妇产科学] R445.2[医药卫生—临床医学]