新疫情防控形势下广州某三甲医院住院病人新型冠状病毒感染率及分析  

Analysis of SARS-CoV-2 Infection Among Inpatients in a Tertiary Hospital in Guangzhou During the Covid-19 Pandemic

作　　者：吴悦 孙潇潇 周晓琪 颜可梁 卢汉威[1] 杨小蓉[1] 杨兆收 WU Yue;SUN Xiao-xiao;ZHOU Xiao-qi;YAN Ke-liang;LU Han-wei;YANG Xiao-rong;YANG Zhao-shou(The First Affiliated Hospital of Guangdong Pharmaceutical University,Guangzhou 510080;Guangdong Pharmaceu-tical University,Guangzhou 510061)

机构地区：[1]广东药科大学附属第一医院,广东广州510080 [2]广东药科大学,广东广州510061

出　　处：《中山大学学报（医学科学版）》2023年第5期878-885,共8页Journal of Sun Yat-Sen University:Medical Sciences

基　　金：广州市重点研发计划农业和社会发展科技项目(202103000051)。

摘　　要：【目的】2022年11月底广州执行最新的新型冠状(新冠)病毒防疫政策,开始逐步解封。在新防疫形势下,国内住院病人新冠病毒感染的情况尚不明确。据此,本文旨在研究新疫情防控形势下广州住院病人的新冠病毒感染情况。【方法】回顾性分析2022年11月底至2023年2月初我院的新冠病毒核酸检测结果。统计分析新防疫形势下医院病人的新冠病毒核酸检测的阳性率,以及住院病人的医院获得性新冠病毒感染率。【结果】回顾性分析了13959人次病人的新冠核酸检测结果,包括6966人次门诊病人和6993人次住院病人。2022年11月30日,门诊病人的新冠病毒核酸检测结果开始出现阳性,新冠疫情已经开始暴发。12月7日,住院病人的新冠病毒核酸检测结果出现阳性,院内感染开始爆发。12月15日,门诊和住院病人的新冠病毒核酸检测阳性率(核酸阳性率)均超过40%,疫情进入高峰期。12月底之后,检测阳性率逐步下降,但住院病人的阳性率一直高于门诊病人。与2022年12月份相比,2023年1月份众多科室病人核酸阳性率明显下降,但肿瘤科病区的住院病人核酸阳性率显著升高(P<0.001)。进一步分析发现,住院病人的医院获得性新冠病毒感染率为86.57%(329/380),淋巴瘤病人的医院获得性新冠病毒感染率[58.33%(14/24)]显著低于其他疾病类型的住院病人(P<0.001)。【结论】医院病人的核酸阳性率在2022年12月中旬达到高峰,在2023年1月逐渐下降,但部分科室核酸阳性人次数或阳性率呈上升趋势。住院病人的医院获得性新冠感染高达九成。不同疾病类型的住院病人的医院内新冠病毒获得性感染存在差异。总之,本研究为广州住院病人的新冠感染的流行性特点以及住院病人感染和医护交叉感染防护提供了初步数据。【Objective】At the end of November 2022,Guangzhou implemented the latest Covid-19 epidemic preven⁃tion policy and began to gradually lift the lockdown.However,under the new epidemic prevention situation,the situation of SARS-CoV-2 infection in hospitalized patients in China is still unclear.Accordingly,this paper aims to study the SARS-CoV-2 infection of hospitalized patients in Guangzhou under the new epidemic prevention and control situation.【Methods】The results of SARS-CoV-2 nucleic acid tests in our hospital from the end of November 2022 to the beginning of February 2023 were retrospectively analyzed.The positive rate of SARS-CoV-2 nucleic acid tests in outpatients and in⁃patients under the new epidemic prevention situation,and the nosocomial infection of SARS-CoV-2 in inpatients were sta⁃tistically analyzed.【Results】This study retrospectively analyzed the SARS-CoV-2 nucleic acid test results of 13959 pa⁃tients,including 6966 outpatients and 6993 inpatients.On November 30,2022,the SARS-CoV-2 nucleic acid test re⁃sults of outpatients began to be positive,indicating that the outbreak of the SARS-CoV-2 infection had begun.On Decem⁃ber 7,one case of SARS-CoV-2 nucleic acid test results of hospitalized patients was positive,and nosocomial infections began to break out.On December 15,the positive rate of SARS-CoV-2 nucleic acid test among patients exceeded 40%,and the epidemic entered its peak period.After the end of December,the test positive rate gradually decreased,but the positive rate of inpatients was always higher than that of outpatients.Compared with December 2022,the positive rate of SARS-CoV-2 nucleic acid test of patients in many departments in January 2023 decreased,but the positive rate of SARS-CoV-2 nucleic acid test of inpatients in the oncology department increased significantly(P<0.001).Further analysis found that the nosocomial infection rate of SARS-CoV-2 in inpatients was 86.57%(329/380).However,the nosocomial infection rate in lymphoma patients[58.33%(14/24)]was signific

关 键 词：新型冠状病毒 门诊病人 住院病人 医院获得性感染 广州 

分 类 号：R181.8[医药卫生—流行病学]