针织导电心肌补片的构建及力电性能  

Construction and mechanoelectrical properties of knitted conductive myocardial patch

作　　者：彭佳敏 李沂蒙 战经环 毛吉富 王璐[1,2,3] PENG Jiamin;LI Yimeng;ZHAN Jinghuan;MAO Jifu;WANG Lu(College of Textiles,Donghua University,Shanghai 201620,China;Key Laboratory of Textile Science&Technology,Ministry of Education,Donghua University,Shanghai 201620,China;Key Laboratory of Biomedical Textile Materials and Technology in Textile Industry,Donghua University,Shanghai 201620,China)

机构地区：[1]东华大学纺织学院,上海201620 [2]东华大学纺织面料技术教育部重点实验室,上海201620 [3]东华大学纺织行业生物医用纺织材料与技术重点实验室,上海201620

出　　处：《东华大学学报（自然科学版）》2023年第4期1-7,43,共8页Journal of Donghua University(Natural Science)

基　　金：上海市自然科学基金(21ZR1401300);国家自然科学基金青年基金(52005097);中央高校基本科研业务费专项资金项目(2232020G-01);东华大学高层次人才科研启动经费资助项目;高等学校学科创新引智计划资助项目(BP0719035)。

摘　　要：为制备一种符合天然心肌组织力电性能的心肌补片,以聚己内酯(polycaprolactone, PCL)为原料,通过针织成型技术制备针织(knitting, Kt)补片,同时制备静电纺丝(electrospinning, Es)补片作为对照样,采用多巴胺(dopamine, DOPA)对Kt、Es补片进行表面改性,再通过表面原位聚合聚吡咯(polypyrrole, PPy)构建PPy@Kt、PPy@Es补片。通过立体显微镜、扫描电子显微镜、红外光谱仪、强力仪及数字源表对心肌补片的结构和物理化学性能进行表征,探究2种纺织成型技术对心肌补片力电性能的影响。结果表明:静电纺丝成型的PPy@Es补片沿取向方向模量大且导电稳定性差,而针织成型的PPy@Kt补片表现出更接近心肌组织的模量且具有力学各向异性,同时展现出优异的应变不敏感导电性,可满足心肌补片对动态应变下稳定导电性的要求。To prepare a myocardial patch that is consistent with the mechanical and electrical mechanoelectrical properties of natural cardiac tissue,knitting(Kt)patches were fabricated using polycaprolactone(PCL)as raw materials,and electrospinning(Es)patches were fabricated as a pair.Surface modification of Kt and Es patches was performed by dopamine(DOPA).PPy@Kt and PPy@Es patches were constructed by in-situ polymerization of polypyrrole(PPy)on the surface.The structure and physical-chemical properties of myocardial patch were characterized by stereomicroscope,scanning electron microscope,infrared spectroscopy,strength analyzer and digital source table,and the influence of two textile forming technologies on the mechanical and electrical mechanoelectrical properties of myocardial patch was investigated.The results show that the PPy@Es patch formed by electrospinning has large modulus and poor conductive stability along the orientation direction,while the PPy@Kt patch formed by knitting shows loser modulus to myocardial tissue and mechanical anisotropy,and excellent strain-insensitive conductivity to meet the requirements of myocardial patch for stable electrical conductivity under dynamic strain.

关 键 词：导电心肌补片 针织 力电性能 聚吡咯 应变不敏感导电性 各向异性 

分 类 号：TS181[轻工技术与工程—纺织材料与纺织品设计] R318.08[轻工技术与工程—纺织科学与工程]