微流纺制备复合载药纤维及其释药性能研究  

Study of PVP/SA/AAP Composite Fiber Prepared by Microfluidic Spinning and Its Drug Release Characteristics

作　　者：方瑛 林红[1,2] 张德锁[1,2] 熊佳庆 陈宇岳[1,2] 

机构地区：[1]苏州大学纺织与服装工程学院 [2]苏州大学现代丝绸国家工程实验室 [3]东华大学纺织科技创新中心

出　　处：《纺织导报》2023年第5期53-56,共4页China Textile Leader

摘　　要：文章以聚乙烯吡咯烷酮(PVP)和海藻酸钠(SA)混合溶液为芯层溶液,氯化钙为鞘流层溶液,对乙酰氨基酚(AAP)为模型药物,采用微流体同轴纺丝技术制备了PVP/SA/AAP复合纤维(PSA复合纤维)。测试结果显示,所得PSA复合纤维性能优良且对AAP具有明显的缓释作用,PSA复合纤维的释药时间长达72 h且累计释药率在60%以上。By taking PVP and SA mixed solution as the core layer solution,calcium chloride as the sheath solution,and AAP as the model drug,the PVP/SA/AAP composite fiber,also known as PSA composite fiber,is prepared by the microfluidic coaxial spinning technology.Results indicate that PSA composite fiber boasts excellent performance and an obvious slow-release effect on AAP,with as long as 72 hours of release time and over 60%of cumulative release.

关 键 词：同轴微流纺 纤维 药物缓释 

分 类 号：TS102.5[轻工技术与工程—纺织工程]