纳米材料与水体其他污染物的复合暴露毒性研究进展  

Research Advances on Composite Exposure Toxicity of Nanomaterials and Other Pollutants in Waters

作　　者：陈晨晨 余澜 周宋奕 裘蕾蕾 郑茹悦 陈瑾[1] Chen Chenchen;Yu Lan;Zhou Songyi;Qiu Leilei;Zheng Ruyue;Chen Jin(College of Medical Technology and Information Engineering,Zhejiang Chinese Medicine University,Hangzhou 310053,China)

机构地区：[1]浙江中医药大学医学技术与信息工程学院,杭州310053

出　　处：《生态毒理学报》2023年第4期174-187,共14页Asian Journal of Ecotoxicology

基　　金：浙江省基础公益研究计划项目(LTGY23B070001);浙江省大学生创新创业训练计划项目(S202210344094)。

摘　　要：纳米材料被广泛应用于食品、医疗、化妆品等领域,大量的纳米材料被排入水体,由此引起广泛的水环境污染问题。纳米材料因其小尺寸,较大比表面积的特性,在环境中极易吸附其他污染物而造成复合暴露风险,增加其生物效应的复杂性。本文着重讨论纳米塑料、氧化石墨烯、纳米二氧化钛及单壁碳纳米管与水环境中农药、重金属、持续性有机污染物等的复合暴露风险及对生物体产生的毒性影响,从纳米材料与水体污染物的交互作用和细胞毒作用机制方面论述了纳米材料介导的复合暴露毒性机理,并就构建复合暴露模型进行展望,提出从分子水平上揭示复合毒性规律的研究方向,为水生态污染风险评估提供依据。Nanomaterials have been widely used in the fields of food,medicine and cosmetic.A large number of nanomaterials have been discharged into water during use,which causes extensive water environmental pollution.Nanomaterials are highly susceptible to adsorption of other contaminants in the environment due to their small size and large specific surface area,resulting in compound exposure risks and the complexity of their biological effects.This paper focused on the risks of compound exposure of nanomaterials,such as nanoplastics,graphene oxide,titanium dioxide nanoparticles and single-walled carbon nanotubes,and pesticides,heavy metals and persistent organic pollutants in the water environment and the toxic effects on organisms.The possible mechanism of composite exposure toxicity mediated by nanomaterials was discussed from the aspects of interaction between nanomaterials and water pollutants and the mechanism of cytotoxicity.The prospect of the construction of composite exposure model has been put forward,and the research direction of revealing the rule of composite toxicity from the molecular level has been proposed,which will provide a basis for the risk assessment of water ecological pollution.

关 键 词：纳米材料 复合暴露 生物毒性 水生态风险 

分 类 号：X171.5[环境科学与工程—环境科学]