蛋鸡卵泡发育及其表观遗传调控机制研究进展  

esearch Progress on Follicles Development of Hens and Its Epigenetic Regulatory Mechanism

作　　者：茹盟 曾文惠 彭剑玲 曾庆节 殷超 崔勇 魏庆[1] 梁海平[1] 谢贤华 黄建珍[1] RU Meng;ZENG Wenhui;PENG Jianling;ZENG Qingjie;YIN Chao;CUI Yong;WEI Qing;LIANG Haiping;XIE Xianhua;HUANG Jianzhen(College of Animal Science and Technology,Jiangxi Agricultural University,Nanchang 330045,China)

机构地区：[1]江西农业大学动物科技学院,南昌330045

出　　处：《畜牧兽医学报》2023年第9期3613-3622,共10页ACTA VETERINARIA ET ZOOTECHNICA SINICA

基　　金：国家自然科学基金(31960690,31460648)。

摘　　要：家禽的繁殖性能、产蛋性能与卵泡的正常发育和排卵密切相关。家禽卵巢中大部分的卵泡在发育过程中发生闭锁,只有大约不到5%的卵泡可以从原始卵泡发育至成熟卵泡并排卵。鸡的卵泡发育主要受内在因素(激素和细胞因子等)和外在因素(营养水平等)调节。近来,越来越多的研究发现表观遗传也在卵泡发育中起着重要的调控作用。表观遗传学是指在DNA序列不发生改变的情况下,基因表达及表型产生可遗传的变化。因此,文章综述了蛋鸡卵泡发育的过程及主要影响因素,同时从DNA甲基化、组蛋白修饰、非编码RNA调控以及RNA修饰4个方面综述了表观遗传在卵泡发育中的可能调控机制,旨在为提高家禽生产性能提供一定的理论基础。The reproductive performance and egg production performance of poultry is closely related to follicles development and ovulation.In poultry ovaries,less than 5%of follicles can develop from primordial follicle to mature follicle and ovulate,and most follicles become atresia during development.The development of follicles is influenced by intrinsic factors and extrinsic factors.Recently,many studies have found that epigenetic mechanism also plays an important role in the regulation of follicle development.Epigenetics is heritable changes in gene expression and phenotype without changing in the DNA sequence.Therefore,the review described the process of follicle development and the main influencing factors in follicle development in laying hens.Moreover,in this review,the possible epigenetics regulatory mechanisms including DNA methylation,histone modification,non-coding RNA regulation and RNA modification in follicle development were summarized.In conclusion,the review provides a theoretical basis for improving poultry production performance.

关 键 词：蛋鸡 卵泡发育 影响因素 表观遗传 

分 类 号：S831.3[农业科学—畜牧学]