一例安德鲁貂尾尖软骨样脊索瘤的组织病理学观察及分析  

A Case Report on Pathological Diagnosis and Analysis of Chondroid Chordoma in Anglo mink

作　　者：龙美贞 李浩运 董玉慧 南岳 周向梅[1] LONG Meizhen;LI Haoyun;DONG Yuhui;NAN Yue;ZHOU Xiangmei(National Key Laboratory of Veterinary Public Health Security,College of Veterinary Medicine,China Agricultural University,Beijing 100193,China;China Agricultural University Veterinary Teaching Hospital,Beijing 100193,China)

机构地区：[1]中国农业大学动物医学院兽医公共卫生安全全国重点实验室,北京100193 [2]中国农业大学动物医院,北京100193

出　　处：《畜牧兽医学报》2023年第9期3998-4002,共5页ACTA VETERINARIA ET ZOOTECHNICA SINICA

摘　　要：1例3岁雄性家养安德鲁貂,因尾尖有一缓慢生长的肿物而就诊,通过手术完全切除肿物,并对其进行组织病理学检查。结果显示,最后尾椎骨被一个由大的多角形细胞组成的分叶状肿瘤取代,肿瘤细胞的细胞质表现为高度空泡化(physaliferous cells),并可见胞质内PAS(Periodic Acid-Schiff)染色阳性颗粒。免疫组织化学显示细胞质对细胞角蛋白(cytokeratin,CK)和波形蛋白(vimentin)以及中枢神经特异蛋白(S-100)呈阳性。组织形态学特征和免疫组化结果与人的软骨样脊索瘤一致。本文描述了该病例的组织形态学特征和免疫组织化学结果,并回顾相关文献资料,可以为该肿瘤的诊疗和预后提供参考依据。A 3-year-old,male domestic Anglo mink was presented with a slow-growing mass on the tail tip.The mass was completely removed by surgery.Histological examination performed on the mass revealed a lobulated neoplasm composed of large polygonal cells replaced the last coccygeal vertabra.The neoplastic cells had highly vacuolated cytoplasm(physaliferous cells)and intracytoplasmic Periodic Acid-Schiff-positive granules.Immunohistochemistry revealed cytoplasmic positivity for cytokeratin,vimentin and S-100.Histomorphological features and immunohistochemical results consistent with a chondroid chordoma of humans.This case report described Histomorphological features and immunohistochemical results in chondroid chordoma located at the tail of Anglo mink,and reviews the relevant literature,which can provide a reference for the diagnosis and prognosis of the tumor.

关 键 词：安德鲁貂 尾尖 软骨样脊索瘤 组织病理学 免疫组织化学 

分 类 号：S857.4[农业科学—临床兽医学]