单球囊双侧序贯扩张经皮椎体后凸成形术治疗骨质疏松性椎体压缩性骨折的临床效果  

Clinical effect of single balloon bilateral sequential dilatation percutaneous kyphoplasty in the treatment of osteoporotic vertebral compression fractures

作　　者：李永恒 梁志强 顾世勤 LI Yongheng;LIANG Zhiqiang;GU Shiqin(the First People's Hospital of Xianyang,Xianyang 721000;Xianyang Hospital of Yan'an University,Xianyang 721000,China)

机构地区：[1]咸阳市第一人民医院,陕西咸阳721000 [2]延安大学咸阳医院,陕西咸阳721000

出　　处：《临床医学研究与实践》2023年第28期38-41,共4页Clinical Research and Practice

基　　金：2020年度院内科学研究基金项目(No.2020ZX011)。

摘　　要：目的探讨单球囊双侧序贯扩张经皮椎体后凸成形术治疗骨质疏松性椎体压缩性骨折的临床效果。方法选取2019年10月至2021年10月收治的110例骨质疏松性椎体压缩性骨折患者为研究对象,根据手术方式不同将其分为对照组和观察组,各55例。对照组采用单球囊单侧扩张经皮椎体后凸成形术,观察组采用单球囊双侧序贯扩张经皮椎体后凸成形术。比较两组的治疗效果。结果观察组的治疗总有效率高于对照组(P<0.05)。术后3个月,观察组的椎体前缘高度大于对照组,Cobb角小于对照组(P<0.05)。术后3个月,观察组的瘦素、Ⅰ型前胶原氨基端肽(PⅠNP)水平低于对照组(P<0.05)。术前及术后1周、3个月,两组的皮质醇(Cor)、肾上腺素(E)水平比较,差异无统计学意义(P>0.05);术后1周,两组的Cor、E水平高于术前(P<0.05);术后3个月,两组的Cor、E水平低于术后1周(P<0.05)。结论单球囊双侧序贯扩张经皮椎体后凸成形术有助于提高骨质疏松性椎体压缩性骨折患者的治疗效果和椎体稳定性,下调瘦素、PⅠNP水平,且不会增加机体应激反应。Objective To investigate the clinical effect of single balloon bilateral sequential dilatation percutaneous kyphoplasty in the treatment of osteoporotic vertebral compression fractures.Methods A total of 110 patients with osteoporotic vertebral compression fractures admitted from October 2019 to October 2021 were selected as the research objects.According to different surgical methods,the patients were divided into control group and observation group,with 55 cases in each group.The control group was treated with single balloon unilateral dilatation percutaneous kyphoplasty,and the observation group was treated with single balloon bilateral sequential dilatation percutaneous kyphoplasty.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05).At 3 months after operation,the anterior height of vertebral body in the observation group was greater than that in the control group,and the Cobb angle was less than that in the control group(P<0.05).At 3 months after operation,the levels of leptin and typeⅠprocollagen N-terminal peptide(PⅠNP)in the observation group were lower than those in the control group(P<0.05).Before operation,1 week and 3 months after operation,there were no significant differences in the levels of cortisol(Cor)and epinephrine(E)between the two groups(P>0.05);one week after operation,the levels of Cor and E in the two groups were higher than those before operation(P<0.05);at 3 months after operation,the levels of Cor and E in the two groups were lower than those at 1 week after operation(P<0.05).Conclusion Single balloon bilateral sequential dilatation percutaneous kyphoplasty is helpful to improve the therapeutic effect and vertebral stability of patients with osteoporotic vertebral compression fractures,down-regulate the levels of leptin and PⅠNP,and will not increase the body's stress response.

关 键 词：骨质疏松 椎体压缩性骨折 经皮椎体后凸成形术 单球囊双侧序贯扩张 

分 类 号：R687.3[医药卫生—骨科学]