犬尿氨酸途径:帕金森病运动防治的一种可能新机制  

Kynurenine Pathway:A Possible New Mechanism for Exercise In the Prevention and Treatment of Parkinson’s Disease

作　　者：李刚强 耿小飞 周文辉[1] 陈平[1] LI Gangqiang;GENG Xiaofei;ZHOU Wenhui;CHEN Ping(Jishou University,Jishou 416000,China;Hebei Normal University for Nationalities,Chengde 067000,China)

机构地区：[1]吉首大学,湖南吉首416000 [2]河北民族师范学院,河北承德067000

出　　处：《中国体育科技》2023年第9期63-71,共9页China Sport Science and Technology

基　　金：湖南省自然科学基金项目(2021JJ30552);湖南省教育厅科学研究项目(19B469);国家民族体育重点研究基地开放基金项目(MZTY2203)。

摘　　要：帕金森病(Parkinson’s disease,PD)是一种与年龄相关的神经退行性疾病。犬尿氨酸途径(Kynurenine pathway,KP)是PD发生发展相关因素(中枢神经炎症、谷氨酸兴奋性毒作用和多巴胺耗竭等)的共同作用通路。KP主要酶系的调节剂(如抑制剂或激动剂)及其主要神经保护性代谢产物对缓解PD进展有益。运动可显著改善PD相关行为功能障碍,也可以影响KP代谢动力学。促进KP产生神经保护性活性代谢产物可能是运动改善PD相关行为功能障碍的中枢机制之一。本文从KP入手,对其在PD神经退行性病变及PD运动防治中的可能作用进行综述。Parkinson’s disease(PD)is an age-related neurodegenerative disease.Kynurenine pathway(KP)is a common pathway of related factors(central nervous system inflammation,excitotoxic effects of glutamate and dopamine depletion,etc.)of PD occurrence and development.Regulators of the main enzyme systems of KP(such as inhibitors and activators)and their major neuroprotective metabolic products are beneficial in alleviating the progression of PD.Exercise significantly improves PD-related behavioral dysfunction,and can affect KP pharmacokinetics.Promoting the production of neuroprotective active metabolites by KP may be one of the central mechanisms by which exercise improves PD-related behavioral dysfunction.Starting from KP,this paper reviews the possible role of KP in the PD neurodegeneration and PD exercise prevention and treatment.

关 键 词：运动 帕金森病 犬尿氨酸途径 犬尿喹啉酸 喹啉酸 

分 类 号：G804.5[文化科学—运动人体科学]