NR4A1在糖尿病肾病发病中作用的研究进展  

Progress in the role of NR4A1 in the development of diabetic nephropathy

作　　者：吕文玥 李金梦 李含 刘雷[2] 王娜[2] LYU Wenyue;LI Jinmeng;LI Han;LIU Lei;WANG Na(Clinical Medical College,Jining Medical University,Jining 272029;Department of General Practice,Affiliated Hospital of Jining Medical University,Jining 272029,China)

机构地区：[1]济宁医学院临床医学院,山东济宁272029 [2]济宁医学院附属医院全科医学科,山东济宁272029

出　　处：《基础医学与临床》2023年第10期1608-1611,共4页Basic and Clinical Medicine

基　　金：济宁医学院贺林院士新医学临床转化工作站科研基金(JYHL2022FMS02)。

摘　　要：NR4A1作为核受体亚家族的一员,与糖脂代谢关键酶甘油激酶共同作用,可以降低血糖,升高血脂,维持糖脂平衡;而NR4A1的缺失又会导致肝脏糖脂代谢的紊乱。NR4A1参与维持氧化/抗氧化动态平衡,降低炎性反应,促进自噬等活动。因与糖尿病肾病等疾病发生关系密切,近年来NR4A1引起人们广泛关注。As a member of the nuclear receptor subfamily,NR4A1 works with glycerol kinase,a key glucose and lipid metabolism enzyme,to lower blood glucose and boost blood lipids and maintain glucose and lipid homeostasis,while NR4A1 deficiency leads to disruption of hepatic glucose and lipid metabolism.NR4A1 is involved in maintaining the dynamic balance of oxide and antioxidants,reducing inflammatory responses,and promoting autophagy,among other activities.Since NR4A1 is closely related to the occurrence of diabetic nephropathy and other diseases,it has aroused widespread concern in recent years.

关 键 词：NR4A1 糖尿病肾病 

分 类 号：R587.2[医药卫生—内分泌]