小儿咽扁颗粒联合常规西药治疗小儿甲型流行性感冒伴热性惊厥的效果  

Effects of Xiaoer Yanbian granules combined with conventional western medicine in treatment of influenza A with febrile convulsion in children

作　　者：程皓文 CHENG Haowen(Department of Pediatrics of West Hospital of Xiushui County First People’s Hospital,Jiujiang 332418 Jiangxi,China)

机构地区：[1]修水县第一人民医院西院儿科,江西九江332418

出　　处：《中国民康医学》2023年第18期129-131,135,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察小儿咽扁颗粒联合常规西药治疗小儿甲型流行性感冒(甲流)伴热性惊厥的效果。方法:回顾性分析2021年12月至2022年12月该院收治的106例甲流伴热性惊厥患儿的临床资料,按照治疗方式不同将其分为对照组和观察组各53例。两组均给予补液、吸氧、镇静等基础治疗,在此基础上,对照组采用常规西药(对乙酰氨基酚+帕拉米韦)治疗,观察组在对照组基础上加用小儿咽扁颗粒。比较两组临床疗效、症状消失时间、住院时间,血清炎性指标[白细胞介素-4(IL-4)、γ干扰素(IFN-γ)、C反应蛋白(CRP)、白细胞计数(WBC)]水平、神经损伤指标[脑源性神经营养因子(BDNF)、中枢神经特异性蛋白(S100β)、神经元特异性烯醇化酶(NSE)]水平,以及不良反应发生率。结果:观察组治疗总有效率为96.23%(51/53),显著高于对照组的77.36%(41/53),差异有统计学意义(P<0.05);观察组退热时间,惊厥、咳嗽、鼻塞、咽痛消失时间,以及住院时间均显著短于对照组,差异有统计学意义(P<0.05);治疗后,观察组血清IL-4、CRP、IFN-γ、BDNF、S100β、NSE水平及WBC值均低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:小儿咽扁颗粒联合常规西药治疗甲流伴热性惊厥患儿可提高疗效,加快临床症状消失,降低血清炎性指标水平,减轻神经损伤程度,效果优于单用常规西药治疗。Objective:To observe effects of Xiaoer Yanbian granules combined with conventional western medicine in treatment of influenza A(H1N1)with febrile convulsion in children.Methods:The clinical data of 106 children with influenza A and febrile convulsion admitted to this hospital from December 2021 to December 2022 were retrospectively analyzed.According to different treatment methods,they were divided into control group and observation group,53 cases in each group.Both groups were given basic treatment such as fluid infusion,oxygen inhalation and sedation.On this basis,the control group was treated with conventional western medicine(Acetaminophen+Peramivir),while the observation group was treated with Xiaoer Yanbian granules on the basis of that of the control group.The clinical efficacy,the symptom resolution time,the hospitalization time,the serum inflammatory factor levels[interleukin-4(IL-4),interferon-γ(IFN-γ),C-reactive protein(CRP),white blood cell count(WBC)],the serum nerve injury index levels[brain-derived neurotrophic factor(BDNF),Central nerve Specific Protein(S100β),neuron-specific enolase(NSE)]levels,and the incidence of adverse reactions were compared between the two groups before and after the treatment.Results:The total effective rate of the observation group was 96.23%(51/53),which was significantly higher than the control group of 77.36%(41/53),and the difference was statistically significant(P<0.05).The antipyretic time,the disappearance time of convulsion,cough,nasal congestion and sore throat,and the hospitalization time in the observation group were significantly shorter than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of serum IL-4,CRP,IFN-γ,BDNF,S100β,NSE and WBC in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the rate of adverse reactions between the two groups(P>0.05).Conclusions:Xiaoer Ya

关 键 词：小儿咽扁颗粒 对乙酰氨基酚 帕拉米韦 甲型 流行性感冒 儿童 热性惊厥 

分 类 号：R725.1[医药卫生—儿科]