早期综合性康复干预对脑损伤早产儿预后转归的改善作用  

Improvement effect of early comprehensive rehabilitation intervention on prognosis of premature infants with brain injury

作　　者：李莹 周曼丽[1] 黄玉焕[1] LI Ying;ZHOU Man-li;HUANG Yu-huan(Neonatal Intensive Care Department,Nanyang First People's Hospital,Nanyang 473001,Henan,CHINA)

机构地区：[1]南阳市第一人民医院新生儿重症监护科,河南南阳473001

出　　处：《海南医学》2023年第18期2661-2665,共5页Hainan Medical Journal

基　　金：河南省南阳市2020年市级科技计划项目(编号:KJGG186)。

摘　　要：目的探究早期综合性康复干预在脑损伤早产儿中的应用效果。方法选取2020年7月至2022年7月南阳市第一人民医院收治的180例脑损伤早产儿为研究对象,依据随机数表法分为对照组和观察组各90例,对照组早产儿给予常规康复干预,观察组早产儿在对照组基础上给予早期综合性康复干预,两组早产儿均干预12个月,比较两组早产儿的预后转归情况、胃肠道功能及干预前后的营养状况[前白蛋白(PA)、视黄醇结合蛋白(RBP)、白蛋白(ALB)]。结果观察组早产儿的神经系统后遗症发生率为5.56%,明显低于对照组的15.56%,差异有统计学意义(P<0.05);观察组早产儿的胎便初排时间、日排便次数、全肠道喂养时间和胎便转黄时间分别为(17.41±3.51)h、(9.14±2.82)次、(11.64±2.06)d、(42.14±7.48)h,明显短于对照组的(22.94±3.42)h、(10.36±3.76)次、(14.09±2.76)d、(46.72±8.03)h,差异均有统计学意义(P<0.05);矫正3个月龄时,观察组早产儿的PA、RBP、ALB分别为(154.45±26.58)mg/L、(20.41±2.58)mg/L、(34.58±4.28)g/L,明显高于对照组的(144.94±23.79)mg/L、(16.67±3.16)mg/L、(29.40±5.12)g/L,差异均有统计学意义(P<0.05);矫正12个月龄时,观察组早产儿的PA、RBP、ALB分别为(174.56±19.15)mg/L、(25.45±2.81)mg/L、(42.14±5.87)g/L,明显高于对照组早产儿(163.56±22.71)mg/L、(20.87±2.55)mg/L、(39.47±6.63)g/L,差异均有统计学意义(P<0.05)。结论早期综合性康复干预应用于脑损伤早产儿中,可促进早产儿肠道功能恢复,提高营养指标,减轻神经伤残风险,促进预后恢复。Objective To explore the effect of early comprehensive rehabilitation intervention in premature infants with brain injury.Methods A total of 180 preterm infants with brain injury admitted to Nanyang First People's Hospital from July 2020 to July 2022 were selected and divided into in the control group and the observation group according to the random number table method,each with 90 cases.Infants in the control group were given conventional rehabilitation interventions,while those in the observation group were given early comprehensive rehabilitation interventions on the basis of the control group,for 12 months.Prognostic outcome,gastrointestinal function,and nutritional status before and after the interventions[pro-albumin(PA),retinol-binding protein(RBP),albumin(ALB)]were compared between the two groups.Results The incidence rate of neurological sequelae in preterm infants in the observation group was 5.56%,which was significantly lower than 15.56%in the control group(P<0.05).The time for first evacuation of foetal stools,the number of daily defecations,the time of full intestinal feedings,and the time for foetal stools to turn yellow in the observation group were(17.41±3.51)h,(9.14±2.82)times,(11.64±2.06)d,(42.14±7.48)h,which were significantly shorter than(22.94±3.42)h,(10.36±3.76)times,(14.09±2.76)d,and(46.72±8.03)h in the control group(P<0.05).At the corrected age of 3 months,PA,RBP,and ALB of preterm infants in the observation group were(154.45±26.58)mg/L,(20.41±2.58)mg/L,(34.58±4.28)g/L,respectively,which were significantly higher than(144.94±23.79)mg/L,(16.67±3.16)mg/L,and(29.40±5.12)g/L of the control group(P<0.05);at the corrected age of 12 months,the PA,RBP,and ALB of preterm infants in the observation group were(174.56±19.15)mg/L,(25.45±2.81)mg/L,and(42.14±5.87)g/L,respectively,which were significantly higher than(163.56±22.71)mg/L,(20.87±2.55)mg/L,(39.47±6.63)g/L in the control group(P<0.05).Conclusion Early comprehensive rehabilitation intervention in premature infants with brai

关 键 词：早产儿 脑损伤 综合性康复干预 神经功能 肠道功能 

分 类 号：R722[医药卫生—儿科]