感染性疾病早产儿血清25-(OH)D3、IL-12、HNL水平变化及其临床意义  

Changes of serum 25 hydroxyvitamin D3,interleukin-12,and human neutrophil lipocalin levels in preterm infants with infectious diseases and their clinical significance

作　　者：程巧林 王丹虹 卢田甜 刘敏 CHENG Qiao-lin;WANG Dan-hong;LU Tian-tian;LIU Min(Haikou People's Hospital(Haikou Affiliated Hospital of Central South University Xiangya School of Medicine),Haikou 570208,Hainan,CHINA)

机构地区：[1]海口市人民医院(中南大学湘雅医学院附属海口医院)儿科,海南海口570208

出　　处：《海南医学》2023年第18期2691-2695,共5页Hainan Medical Journal

基　　金：海南省卫生健康行业科研项目(编号:20A200458)。

摘　　要：目的探讨血清25-羟基维生素D3[25-(OH)D3]、白介素(IL)-12、中性粒细胞载脂蛋白(HNL)水平对感染性疾病早产儿的预测价值。方法选取2015年1月至2020年12月海口市人民医院诊治的226例感染性疾病早产儿作为感染组,根据新生儿感染情况将其分为重度感染组117例和轻度感染组109例,同时选取同期80例未发生感染的早产儿作为对照组。收集各组早产儿的临床资料,检测其血清25-(OH)D3、IL-12、HNL水平,应用受试者工作特征曲线(ROC)分析血清25-(OH)D3、IL-12、HNL水平对感染性疾病早产儿的预测价值。结果感染组早产儿血清25-(OH)D3水平为(11.74±2.56)nmol/L,明显低于对照组的(17.78±5.65)nmol/L,而血清IL-12和HNL水平分别为197.95(123.18,254.83)ng/L、160.17(111.06,194.35)ng/mL,明显高于对照组的66.18(40.76,93.34)ng/L、54.75(38.39,72.17)ng/mL,差异均有统计学意义(P<0.05);轻度感染组早产儿的血清25-(OH)D3水平为(10.53±2.38)nmol/L,明显高于重度感染组的(13.04±2.08)nmol/L,而血清IL-12和HNL水平分别为230.15(167.45,283.29)ng/L、175.85(135.83,225.73)ng/mL,明显低于重度感染组的172.83(104.59,230.17)ng/L、130.43(84.37,174.66)ng/mL,差异均有统计学意义(P<0.01);经ROC分析结果显示,血清25-(OH)D3、IL-12、HNL水平预测感染性疾病早产儿曲线下面积(AUC)分别为0.839、0.877、0.864;当截断值为14.76 nmmol/L、112.81 ng/L、89.56 ng/mL时,灵敏度为89.82%、79.65%、81.86%,特异度为71.25%、88.75%、87.50%;联合预测感染性早产儿AUC为0.966,灵敏度和特异度分别为87.61%、93.75%。结论感染性疾病早产儿血清25-(OH)D3水平下降、IL-12和HNL水平升高,与病情密切相关,可作为预测感染性疾病早产儿的生物标志物,三者联合应用价值优于单独应用。Objective To explore the predictive value of serum 25 hydroxyvitamin D3[25-(OH)D3],interleukin-12(IL-12),and human neutrophil lipocalin(HNL)levels in premature infants with infectious diseases.Methods A total of 226 premature infants with infectious diseases treated in Haikou People's Hospital from January 2015 to December 2020 were selected as the infection group.According to the infection status of premature infants,they are divided into a severe infection group(n=117)and a mild infection group(n=109).At the same time,80 preterm infants without infection were selected as the control group.Clinical data were collected for the preterm infants in each group.25-(OH)D3,IL-12,and HNL level were detected.The receiver operating characteristic curve(ROC)was used to analyze the predictive value of serum 25-(OH)D3,IL-12,and HNL levels in premature infants with infectious diseases.Results The serum 25-(OH)D3 level in the infection group was(11.74±2.56)nmol/L,which was significantly lower than(17.78±5.65)nmol/L in the control group,and the serum IL-12 and HNL levels were 197.95(123.18,254.83)ng/L,160.17(111.06,194.35)ng/mL in the infection group,respectively,significantly higher than 66.18(40.76,93.34)ng/L,54.75(38.39,72.17)ng/mL in the control group(P<0.05).The levels of serum 25-(OH)D3 in the mild infection group was(10.53±2.38)nmol/L,which was significantly higher than(13.04±2.08)nmol/L in the severe infection group,and the serum IL-12 and HNL were 230.15(167.45,283.29)ng/L,175.85(135.83,225.73)ng/mL in mild infection group,significantly lower than 172.83(104.59,230.17)ng/L,130.43(84.37,174.66)ng/mL in the severe infection group(P<0.01).The ROC analysis showed that the serum 25-(OH)D3 IL-12,and HNL levels in predicting preterm infants with infectious diseases were 0.839,0.877,and 0.864,respectively.When the cut-off values were 14.76 nmmol/L,112.81 ng/L,and 89.56 ng/mL,the sensitivity was 89.82%,79.65%,and 81.86%,and the specificity was 71.25%,88.75%,and 87.50%.The AUC of combined detection of the three indexes for pr

关 键 词：感染性疾病 早产儿 25羟基维生素D3 白介素-12 中性粒细胞载脂蛋白 预测价值 

分 类 号：R722[医药卫生—儿科]