成人乙型肝炎疫苗全程接种的影响因素及免疫效果分析  

Analysis on Influencing Factors and Immune Effect of Whole Course Hepatitis B Vaccination in Adults

作　　者：徐永娟 杨长凤[1] Xu Yongjuan;Yang Changfeng(Department of Preventive Health,Huilongguan Community Health Service Center of Changping District,Beijing 100096,China)

机构地区：[1]北京市昌平区回龙观社区卫生服务中心预防保健科,北京100096

出　　处：《中国社区医师》2023年第26期143-145,共3页Chinese Community Doctors

摘　　要：目的:探讨成人乙型肝炎(简称乙肝)疫苗全程接种的影响因素,对免疫效果进行分析。方法:选取2021年1月—2022年8月于北京市昌平区回龙观社区卫生服务中心接种乙肝疫苗的367名成人作为研究对象,收集基本资料,根据是否全程接种乙肝疫苗分为全程接种组(n=171)和未全程接种组(n=196)。采用多因素Logisitic回归分析乙肝疫苗全程接种的影响因素,比较两组乙肝表面抗原(HBsAg)阳性率及乙肝表面抗体(HBsAb)阳性率。结果:年龄、文化程度、乙肝家族史、职业、乙肝知识认知情况是乙肝疫苗全程接种的独立影响因素,差异有统计学意义(P<0.05)。全程接种组者HBsAg阳性率低于未全程接种组,HBsAb阳性率高于未全程接种组,差异有统计学意义(P<0.05)。结论:成人乙肝疫苗全程接种的相关影响因素较多,有必要加强健康宣教,提高疫苗全程接种率及免疫效果,降低乙肝病毒感染风险。Objective:To explore the influencing factors for the whole course hepatitis B vaccination in adults and analyze the immune effect.Methods:From January 2021 to August 2022,367 adults who received hepatitis B vaccine at Huilongguan Community Health Service Center of Changping District,Beijing were selected as the study subjects.Their basic data were collected,and they were divided into whole course vaccination group(n=171)and non-whole course vaccination group(n=196)according to whether they received whole course hepatitis B vaccination.Multivariate Logistic regression analysis was used to analyze the influencing factors of whole course hepatitis B vaccine vaccination.The positive rates of hepatitis B surface antigen(HBsAg)and hepatitis B surface antibody(HBsAb)were compared between the two groups.Results:Age,education level,family history of hepatitis B,occupation,and knowledge of hepatitis B were independent influencing factors of whole course hepatitis B vaccination,and the differences were statistically significant(P<0.05).The positive rate of HBsAg in the whole course vaccination group was lower than that in the non-whole course vaccination group,and the positive rate of HBsAb in the whole course vaccination group was higher than that in the non-whole course vaccination group,and the difference was statistically significant(P<0.05).Conclusion:There are many influencing factors related to the whole course hepatitis B vaccination in adults.It is necessary to strengthen health education,increase whole course hepatitis B vaccination rate and enhance immune effect,and reduce the risk of hepatitis B virus infection.

关 键 词：成人 乙肝疫苗 全程接种 免疫 

分 类 号：R186[医药卫生—流行病学]