基于加权TOPSIS法的硫酸依替米星注射液药物利用评价  

Drug use evaluation of etimicin sulfate injection based on weighted TOPSIS method

作　　者：郝晓慧 付桂英 王青云 武璐璐 王丽华 HAO Xiao-hui;FU Gui-ying;WANG Qing-yun;WU Lu-lu;WANG Li-hua(The Fifth Medical Centre,Southern District of Chinese PLA General Hospital,Beijing100071,China)

机构地区：[1]解放军总医院第五医学中心南院区药剂科,北京100071

出　　处：《中华医院感染学杂志》2023年第14期2100-2105,共6页Chinese Journal of Nosocomiology

基　　金：北京市G20工程支撑保障基金资助项目(Z161100001816002)。

摘　　要：目的建立硫酸依替米星注射液的药物利用评价(DUE)标准,并采用加权逼近理想解排序法(TOPSIS)对硫酸依替米星注射液的药物使用情况进行评价,为规范其临床合理使用提供参考依据。方法以硫酸依替米星注射液的说明书为基础,结合相关文献及国内外指南建立硫酸依替米星注射液的DUE细则,并以此标准细则为依据,运用加权TOPSIS法对解放军总医院第五医学中心(南院区)2021年1月-2021年12月133例硫酸依替米星注射液的使用情况进行合理性评价。结果在评价的133份病历中,其中相对接近度(Ci)≥80%的评价为合理,有5例(3.76%);Ci值介于79%~60%的评价为基本合理,有80例(60.15%);Ci值<60%的为不合理,有48例(占36.09%)。18个二级指标中不合理问题主要表现在疾病诊断与替代药物的选择、细菌培养及药敏试验、滴注时间、不良药物相互作用等方面。结论加权TOPSIS法用于硫酸依替米星注射液的合理性评价具有可行性,综合多指标,评价结果更加科学客观,规范合理。评价结果反映出了硫酸依替米星注射液在使用过程中存在的不合理现象及具体问题,对此医院需加强监管,进一步促进和规范其合理用药。OBJECTIVE To establish the drug utilization evaluation(DUE)criteria for etimicin sulfate injection and evaluate the use of etimicin sulfate injection by technique for order preference by similarity to ideal solution(TOPSIS)so as to provide guidance for reasonable clinical antibiotics.METHODS The detailed rules and regulations of DUE for etimicin sulfate injection were established based on the instructions of etimicin sulfate injection in combination with relevant literatures and national and international guidelines.On the basis of the detailed rules and regulations,the reasonability of use of etimicin sulfate injection was evaluated for 133patients who were treated in the Fifth Medical Center(South District)of Chinese PLA General Hospital from Jan 2021to Dec 2021by using TOPSIS method.RESULTS Among the 133medical records,5(3.76%)cases were with the relative proximity(Ci)no less than 80%,which was evaluated as reasonable;80(60.15%)cases were with the Ci ranging between 79%and 60%,which was evaluated as basically reasonable;48(36.09%)cases were with the Ci less than 60%,which was evaluated as unreasonable.Among 18secondary evaluation indicators,the major ones that were evaluated as unreasonable included disease diagnosis and choice of alternative drugs,bacterial culture and drug susceptibility testing,duration of infusion and adverse drug interactions.CONCLUSIONThe weighted TOPSIS method is feasible for evaluation of rationality of etimicin sulfate injection,and the evaluation result is more scientific,objective,standardized and reasonable when it is combined with multiple indexes.The evaluation result reflects the unreasonable phenomenon and detailed problems during the process of use of timicin sulfate injection,and it is necessary for the hospital to strengthen the supervision and further promote and regulate the reasonable use of drugs.

关 键 词：硫酸依替米星 注射液 加权TOPSIS法 药物利用评价 层次属性模型 合理用药 

分 类 号：R969.3[医药卫生—药理学]