肺结节动物模型的研究进展  

Progress in animal models of pulmonary nodules

作　　者：赵亚昆 邵栋 郑瑜佳 张珂煜 田燕歌[1,3] 李建生[1,2] ZHAO Yakun;SHAO Dong;ZHENG Yujia;ZHANG Keyu;TIAN Yange;LI Jiansheng(Collaborative lnnovation Center for Chinese Medicine and Respiratory Diseases Coconstructed by Henan Province&Ministry of Education,Henan Key Laboratory of Chinese Medicine for Respiratory Disease,Zhengzhou 450046,China;The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450046,China;Henan University of Chinese Medicine Academy of Chinese Medical Sciences,Zhengzhou 450046,China)

机构地区：[1]河南中医药大学呼吸疾病中医药防治省部共建协同创新中心,河南省中医药防治呼吸病重点实验室,河南郑州450046 [2]河南中医药大学第一附属医院,河南郑州450046 [3]河南中医药大学中医药科学院,河南郑州450046

出　　处：《中国病理生理杂志》2023年第9期1683-1690,共8页Chinese Journal of Pathophysiology

基　　金：河南省高等学校重点科研项目(No.21A360007);河南省中医药科学研究专项课题(No.2021JDZY029)。

摘　　要：近年来,随着多层计算机断层扫描的普遍应用和肺癌筛查的广泛实施,肺结节在全球的检出率显著提高[1-2]。临床上对于进展缓慢或长期不变化的结节多以随访观察为主,缺乏有效预防和治疗药物[3]。稳定且可重复的、接近临床病理特征的肺结节动物模型不仅是肺结节发病机制研究的关键工具,而且在治疗肺结节、预防肺癌的药物研发中有着无可替代的地位。临床上常见的肺结节类型包括肉芽肿性结节、腺瘤、非典型腺瘤样增生(atypical adenomatous hyperplasia,AAH)、早期腺癌等,肺结节动物模型也以此类型多见[4]。A pulmonary nodule(PN)is characterized by a round or irregular lesion in the lung with a diame-ter≤3 cm.PN is characterized by the following features upon imaging:heightened density,clear or unclear boundaries,without atelectasis,hilar lymph node enlargement,and pleural effusion.However,the pathogenesis of PN remains un-clear,and the current treatment measures have failed to meet the clinical demands.Therefore,animal models of PN are of great significance for investigating its pathogenesis and discovering or optimizing effective drugs and methods for its preven-tion and treatment.This paper summarizes the widely used animal models of PNs.Previous research has shown that the most common animal models were used for granulomas,lung adenomas,atypical adenomatous hyperplasia(AAH),and adenocarcinomas.The experimental animals utilized were A/J mice,C57BL/6 mice,and mice with predominantly EGFR and Kras mutations.Moreover,the chief inducers included carcinogenic compounds,such as benzo(a)pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone(NNK).Furthermore,the preparation methods and model characteristics of PNs were systematically and comprehensively reviewed to provide a strong basis and a valuable reference for the rational selection of animal models for basic research and drug developent.

关 键 词：肺结节 动物模型 肉芽肿性结节 非典型腺瘤样增生 腺癌 

分 类 号：R563[医药卫生—呼吸系统] R363[医药卫生—内科学]