药物相关坏疽性脓皮病的研究进展  

Research progress of drug-induced pyoderma gangrenosum

作　　者：陆美琪 赵洁[2] 单菲[2] 王兴蕾[2] 姜笃银[1,2] Lu Meiqi;Zhao Jie;Shan Fei;Wang Xinglei;Jiang Duyin(Department of Burns and Plastic Surgery,the Second Hospital of Shandong University,Jinan 250033,China;Department of Emergency Medical Center,the Second Hospital of Shandong University,Jinan 250033,China)

机构地区：[1]山东大学第二医院整形烧伤科,济南250033 [2]山东大学第二医院急诊医学中心,济南250033

出　　处：《中华损伤与修复杂志（电子版）》2023年第5期447-450,共4页Chinese Journal of Injury Repair and Wound Healing(Electronic Edition)

基　　金：国家自然科学基金(81873934);王正国创伤医学发展基金会(SZYZ-TR-09);山东大学临床研究中心急危重症重点专项(2021SDUCRCA008);山东省科技攻关项目(2019GGX105011);济南市科技计划项目(202225065)。

摘　　要：药物相关坏疽性脓皮病是一种极其罕见的嗜中性皮肤病,病理生理机制不清,诊断困难,且无统一的治疗方案。药物诱发的坏疽性脓皮病作为一种罕见的药物不良反应常给患者带来极大的痛苦。本文就药物相关坏疽性脓皮病的发病机制、病理学检查、临床表现、诊断与鉴别诊断、治疗方案等方面进行综述,以期为临床工作中药物相关坏疽性脓皮病的诊断与治疗提供参考。Drug-induced pyoderma gangrenosum is an extremely rare neutrophilic dermatoses with unclear pathophysiology,difficult diagnosis and non-uniform treatment protocol.However,drug-induced pyoderma gangrenosum is a rare adverse drug reaction that often causes great suffering to patients.In this article,the pathogenesis,pathological examination,clinical manifestations,diagnosis and differential diagnosis,and treatment options of drug-induced pyoderma gangrenosum were reviewed,with the aim of providing a reference for the diagnosis and treatment of drug-induced pyoderma gangrenosum in clinical practice.

关 键 词：坏疽性脓皮病 中性粒细胞胞外陷阱 机制 治疗 

分 类 号：R658.3[医药卫生—外科学]