度拉糖肽应用于2型糖尿病常规治疗中的临床观察  

Clinical Observation of the Application of Dulaglutide in Routine Treatment of Type 2 Diabetes Mellitus

作　　者：殷旭芳 李娇娇 史明明 李会敏 YIN Xufang;LI Jiaojiao;SHI Mingming;LI Huimin(Luohe Second People's Hospital,Henan Luohe 462000;The First People's Hospital of Pingdingshan,Henan Pingdingshan 467000)

机构地区：[1]漯河市第二人民医院,河南漯河462000 [2]平顶山市第一人民医院,河南平顶山467000

出　　处：《深圳中西医结合杂志》2023年第13期98-100,共3页Shenzhen Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的:研究度拉糖肽应用于2型糖尿病(T2DM)患者常规治疗对临床指标的影响。方法:选取2021年1月至2022年6月漯河市第二人民医院收治的78例T2DM合并体质量超标的患者,随机分为对照组和观察组,每组39例。对照组患者采用常规治疗,观察组患者在常规治疗的基础上应用度拉糖肽治疗,比较两组患者临床指标的变化情况。结果:治疗后,观察组患者血清糖化血红蛋白(Hb A1c)、空腹血糖(FPG)、餐后2 h血糖(2h PG)水平均低于对照组,空腹C肽(FCP)水平高于对照组,差异具有统计学意义(P <0.05);治疗后,观察组患者体质量、体质量指数、腰围均低于对照组,差异具有统计学意义(P <0.05);治疗后,观察组患者三酰甘油、总胆固醇、低密度脂蛋白胆固醇水平均低于对照组,差异具有统计学意义(P <0.05);治疗后,观察组患者血清瘦素、脂联素水平均高于对照组,胰岛素抵抗指数低于对照组,差异具有统计学意义(P <0.05)。结论:度拉糖肽应用于T2DM常规治疗中可进一步改善患者相关临床指标,提高临床疗效。Objective To study the effect of dulaglutide on clinical indexes of patients with type 2 diabetes mellitus(T2DM).Methods 78 patients with T2DM with excessive body mass admitted to Luohe Second People's Hospital from January 2021 to June 2022 were randomly divided into a control group and an observation group,with 39 cases in each group.Patients in the control group received conventional treatment,and patients in the observation group were treated with dulaglutide on the basis of conventional treatment,and the changes of clinical indicators in the two groups were compared.Results After treatment,the the levels of setum glycosylated hemoglobin(HbA1c),fasting blood glucose(FPG)and 2-hours postprandial plasma glucose(2h PG)in the observation group were lower than those in the control group,and the level of serum fasting C-peptide(FCP)was higher than that in the control group,the differences were all statistically significant(P<0.05).After treatment,the body mass,body mass index and waist circumference of the observation group were lower than those of the control group,the differences were statistically significant(P<0.05).After treatment,the levels of triglyceride,total cholesterol and low density lipoprotein–cholesterol in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of serum leptin and adiponectin in the observation group were higher than those in the control group,and insulin resistance index was lower than that in the control group,the differences were statistically significant(P<0.05).Conclusion The application of dulaglutide in the routine treatment of T2DM can further improve the relevant clinical indexes and improve the clinical efficacy.

关 键 词：2型糖尿病 体质量超标 肥胖 度拉糖肽 

分 类 号：R587.1[医药卫生—内分泌]