脉通凝汤联合低分子肝素钙预防髋膝关节置换术后DVT形成的效果  

Effect of Maitongning Decoction Combined with Low Molecular Weight Heparin Calcium on Preventing DVT after Hip and Knee Replacement

作　　者：尚继军 倘艳锋[2] 王战朝[2] SHANG Jijun;TANG Yanfeng;WANG Zhanchao(Zhengzhou Deren Orthopaedic Hospital,Henan Zhengzhou 450000;Luoyang Orthopedic-Traumatological Hospital,Henan Luoyang 471000)

机构地区：[1]郑州德仁骨科医院,河南郑州450000 [2]洛阳正骨医院,河南洛阳471000

出　　处：《深圳中西医结合杂志》2023年第14期26-29,共4页Shenzhen Journal of Integrated Traditional Chinese and Western Medicine

基　　金：河南省中医药科学研究专项课题(20–21ZY1061)。

摘　　要：目的:探讨脉通凝汤联合低分子肝素钙预防髋膝关节置换术后下肢深静脉血栓(DVT)形成的效果。方法:选择2021年1月至2022年12月在郑州德仁骨科医院接受髋膝关节置换术治疗的86例患者,按随机对照原则分对照组和观察组,每组43例。对照组术后给予低分子肝素钙,观察组在对照组基础上联合脉通凝汤治疗,均给予10 d治疗。比较两组患者凝血功能、血液流变学指标、DVT与不良反应的发生率。结果:治疗后,观察组患者凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)均长于对照组,纤维蛋白原(FIB)及D–二聚体(D–D)水平均低于对照组,差异具有统计学意义(P<0.05);治疗后,观察组患者全血高切黏度(HS)、全血低切黏度(LS)、血浆黏度(PV)均低于对照组,差异具有统计学意义(P<0.05);两组患者不良反应发生率比较,差异无统计学意义(P>0.05);观察组患者DVT发生率低于对照组,差异具有统计学意义(P<0.05)。结论:脉通凝汤联合低分子肝素钙可有效预防髋膝关节置换术后DVT形成,改善凝血功能及血液流变学指标,且未增加不良反应。Objective To explore the effect of Maitongning decoction combined with low molecular weight heparin calcium in preventing the formation of deep venous thrombosis(DVT)of lower limbs after hip and knee replacement.Methods A total of 86 patients receiving hip and knee replacement in Zhengzhou Deren Orthopaedic Hospital from January 2021 to December 2022 were selected and divided into a control group and an observation group according to the principle of randomized control,with 43 cases in each group.The control group was given low molecular weight heparin calcium after operation,and the observation group was treated with Maitongning decoction for 10 days.The incidence of coagulation function,hemorheology,DVT and adverse reactions were compared between the two groups.Results After treatment,the prothrombin time(PT),activated partial thromboplastin time(APTT)and thrombin time(TT)in the observation group were all longer than those in the control group,while the levels of fibrinogen(FIB)and D-dimer(D-D)in the observation group were lower than those in the control group,with statistical significance(P<0.05).After treatment,the levels of whole blood high tangential viscosity(HS),whole blood low tangential viscosity(LS)and plasma viscosity(PV)in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).The incidence of DVT in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Maitongning decoction combined with low molecular weight heparin calcium can effectively prevent the formation of DVT after hip and knee replacement,improve coagulation function and hemorheology,and do not increase adverse reactions.

关 键 词：髋膝关节置换术 脉通凝汤 低分子肝素钙 

分 类 号：R61[医药卫生—外科学]