Recent progress in theranostic microbubbles  

作　　者：Ziyao Wang Ziyan Feng Fangxue Du Xi Xiang Xinyi Tang Li Qiu Zhiyong Qian 

机构地区：[1]Department of Medical Ultrasound,West China Hospital of Sichuan University,Chengdu 610041,China [2]State Key Laboratory of Biotherapy and Cancer Center,West China Hospital,Sichuan University and Collaborative Innovation Center of Biotherapy,Chengdu 610041,China

出　　处：《Chinese Chemical Letters》2023年第9期45-54,共10页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China-Sichuan Joint Fund Key Program(No.NSFCU21A20417);the National Natural Science Foundation of China(Nos.NSFC31930067,81971622,82272003);the 135 Project for Disciplines of Excellence,West China Hospital,Sichuan University(No.ZYGD18002,China)。

摘　　要：Ultrasonography is an important complement to clinical diagnosis,and the application of microbubbles effectively improved diagnostic accuracy in echography.In scientific research,the sizes of microbubbles range from nanometers to microns.By optimizing the fabrication process,bubble sizes and ultrasound parameters,microbubbles can also be used for drug delivery and therapeutic monitoring.In this review,we summarize the recent advances in the diagnosis and treatment of microbubbles according to their different components.Modification of microbubble shells allows for more accurate imaging and detection and the combined utilization of US-targeted MB destruction(UTMD)allows for non-invasive,precise and targeted delivery of drug molecules to pathological tissues.These features pave the way for the emerge of theranostic microbubbles by combination of functional compositions and the application of multifunctional materials.Theranostic microbubbles allow for the simultaneous process of diagnosis,visualization of drug delivery and therapeutic monitoring.Ultimately,theranostic microbubbles are promising in clinical practice and would enhance contrast-enhanced US(CEUS)to a new qualitative level.

关 键 词：MICROBUBBLES NANOBUBBLES Ultrasound CEUS CAVITATION THERANOSTICS 

分 类 号：R445.1[医药卫生—影像医学与核医学]