Flavidanolides A and B from Isodon flavidus  

作　　者：Jiang-Hai Ye Guo-Yong Luo Chen-Liang Zhao Zheng-Ming Liang Jin-Huai Wei Ya-Hua Liu Kang He Lu-Tai Pan Jing-Jie Zhang Juan Zou Hong-Jie Zhang 

机构地区：[1]School of Pharmacy,Guizhou University of Traditional Chinese Medicine,Guiyang 550025,China [2]School of Chinese Medicine,Hong Kong Baptist University,Hong Kong SAR 999077,China

出　　处：《Chinese Chemical Letters》2023年第9期160-164,共5页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.82204605);the National Natural Science Foundation of China(No.81560709);the Technology Fund of Guizhou Administration of Traditional Chinese Medicine(No.QZYY-2022019);Science and Technology Tip-top Talent Foundation of Universities in Guizhou Province(No.Qian jiao he KY(2021)034);the Research Grant Council of the Hong Kong Special Administrative Region,China(No.HKBU 12102219);the University Grants Committee of the Hong Kong Special Administrative Region,China(UGC Research Matching Grant Scheme,No.RMG2019_1_19)。

摘　　要：A phytochemical investigation on Isodon flavidus led to the isolation of flavidanolide A(1),a rearranged diterpenoid featuring a six/seven/five-membered tricyclic skeleton,together with flavidanolide B(2),an uncommon heterodimeric diterpenoid consisting of a norabietane and a seco-isopimarane monomeric units.Their structures were elucidated by extensive spectroscopic data and single-crystal X-ray diffraction analyses.Their plausible biosynthetic routes were also proposed.In the bioassay,flavidanolide B was found to exhibit good inhibitory effect against lipopolysaccharide(LPS)-induced nitric oxide(NO)production in RAW264.7 cells comparable to positive control pyrrolidinedithiocarbamate ammonium(PDTC),which provided evidence for the medicinal value of I.flavidus as a folk medicine for treating inflammatory diseases.

关 键 词：Isodon flavidus Rearranged six/seven/five-membered SKELETON Heterodimeric diterpenoid Plausible biosynthetic pathway Antiinflammatory effects 

分 类 号：TQ460.1[化学工程—制药化工]