酸枣仁皂苷B的药理作用研究进展  

Advances in pharmacological effects of jujuboside B

作　　者：董晓娜 李梦婷 谷慧阳 朱业 顾翔 DONG Xiao-na;LI Meng-ting;GU Hui-yang;ZHU Ye;GU Xiang(Medical College,Yangzhou University,Yangzhou 225009,China;Dalian Medical University,Dalian 116044,China;Department of Cardiology,Northern Jiangsu People′s Hospital,Yangzhou 225001,China)

机构地区：[1]扬州大学医学院,江苏扬州225009 [2]大连医科大学,辽宁大连116044 [3]苏北人民医院心血管内科,江苏扬州225001

出　　处：《中国中药杂志》2023年第16期4295-4301,共7页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金青年基金项目(81800250);扬州市“十三五”科教强卫专项医学重点人才项目(ZDRC20181)。

摘　　要：药食两用中药酸枣仁是鼠李科植物酸枣的干燥成熟种子,具有养心补肝、宁心安神、敛汗、生津的功效,广泛应用于心血管、神经和免疫系统相关疾病的治疗和保健。酸枣仁皂苷B(jujuboside B,JuB)是酸枣仁的主要有效活性成分之一,具有多种药理作用和应用价值。该文综述了JuB的化学结构和药理活性等方面的研究进展。JuB具有镇静催眠、抗肿瘤、抗血小板和抗炎等多种生物活性,显示了这种植物化学成分对失眠、肿瘤、冠状动脉疾病、气道炎症和肝损伤等疾病的潜在治疗作用。然而,当前研究的结果存在一些局限性,今后需要进行包括基础研究和临床试验等更全面的研究,以提供更可靠的证据。Ziziphi Spinosae Semen(ZSS)is an edible TCM derived from the dried ripe seeds of Ziziphus jujube Mill.var.spinosa(Bunge)Hu ex H.F.Chou(Rhamnaceae),which has the effects of nourishing the heart,tonifying the liver,calming the heart,tranquilizing the mind,arresting sweating,and promoting fluid production,and is widely used in the treatment and health care of diseases related to cardiovascular,nervous,and immune systems.Jujuboside B(JuB),one of the main active ingredients of ZSS,possesses various pharmacological effects with application values.This paper reviewed the chemical structure and pharmacological effects of JuB.JuB has sedative,hypnotic,antitumor,anti-platelet,anti-inflammatory,and other biological activities,which shows the potential therapeutic effects on insomnia,tumors,coronary artery disease,airway inflammation,and liver injury.However,there are some limitations to the results of current studies.More comprehensive studies,including basic research and clinical trials,need to be carried out to provide more reliable evidence.

关 键 词：酸枣仁皂苷B 药理作用 镇静催眠 抗肿瘤 抗血小板 抗炎 

分 类 号：R285[医药卫生—中药学]